Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study.
Progressive lung disease accounts for the majority of morbidity and mortality observed in cystic fibrosis (CF). Beyond secondhand smoke exposure and socio-economic status, the effect of specific environmental factors on CF lung function is largely unknown.Multivariate regression was used to assess c...
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doaj-e5cf7dc2d16e400786deaf276a82aa0e2020-11-25T02:32:24ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-01611e2778410.1371/journal.pone.0027784Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study.Joseph M CollacoJohn McGreadyDeanna M GreenKathleen M NaughtonChristopher P WatsonTimothy ShieldsScott C BellClaire E WainwrightACFBAL Study GroupGarry R CuttingProgressive lung disease accounts for the majority of morbidity and mortality observed in cystic fibrosis (CF). Beyond secondhand smoke exposure and socio-economic status, the effect of specific environmental factors on CF lung function is largely unknown.Multivariate regression was used to assess correlation between specific environmental factors, the presence of pulmonary pathogens, and variation in lung function using subjects enrolled in the U.S. CF Twin and Sibling Study (CFTSS: n = 1378). Significant associations were tested for replication in the U.S. CF Foundation Patient Registry (CFF: n = 16439), the Australian CF Data Registry (ACFDR: n = 1801), and prospectively ascertained subjects from Australia/New Zealand (ACFBAL: n = 167).In CFTSS subjects, the presence of Pseudomonas aeruginosa (OR = 1.06 per °F; p<0.001) was associated with warmer annual ambient temperatures. This finding was independently replicated in the CFF (1.02; p<0.001), ACFDR (1.05; p = 0.002), and ACFBAL (1.09; p = 0.003) subjects. Warmer temperatures (-0.34 points per °F; p = 0.005) and public insurance (-6.43 points; p<0.001) were associated with lower lung function in the CFTSS subjects. These findings were replicated in the CFF subjects (temperature: -0.31; p<0.001; insurance: -9.11; p<0.001) and similar in the ACFDR subjects (temperature: -0.23; p = 0.057). The association between temperature and lung function was minimally influenced by P. aeruginosa. Similarly, the association between temperature and P. aeruginosa was largely independent of lung function.Ambient temperature is associated with prevalence of P. aeruginosa and lung function in four independent samples of CF patients from two continents.http://europepmc.org/articles/PMC3220679?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Joseph M Collaco John McGready Deanna M Green Kathleen M Naughton Christopher P Watson Timothy Shields Scott C Bell Claire E Wainwright ACFBAL Study Group Garry R Cutting |
spellingShingle |
Joseph M Collaco John McGready Deanna M Green Kathleen M Naughton Christopher P Watson Timothy Shields Scott C Bell Claire E Wainwright ACFBAL Study Group Garry R Cutting Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. PLoS ONE |
author_facet |
Joseph M Collaco John McGready Deanna M Green Kathleen M Naughton Christopher P Watson Timothy Shields Scott C Bell Claire E Wainwright ACFBAL Study Group Garry R Cutting |
author_sort |
Joseph M Collaco |
title |
Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. |
title_short |
Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. |
title_full |
Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. |
title_fullStr |
Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. |
title_full_unstemmed |
Effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. |
title_sort |
effect of temperature on cystic fibrosis lung disease and infections: a replicated cohort study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2011-01-01 |
description |
Progressive lung disease accounts for the majority of morbidity and mortality observed in cystic fibrosis (CF). Beyond secondhand smoke exposure and socio-economic status, the effect of specific environmental factors on CF lung function is largely unknown.Multivariate regression was used to assess correlation between specific environmental factors, the presence of pulmonary pathogens, and variation in lung function using subjects enrolled in the U.S. CF Twin and Sibling Study (CFTSS: n = 1378). Significant associations were tested for replication in the U.S. CF Foundation Patient Registry (CFF: n = 16439), the Australian CF Data Registry (ACFDR: n = 1801), and prospectively ascertained subjects from Australia/New Zealand (ACFBAL: n = 167).In CFTSS subjects, the presence of Pseudomonas aeruginosa (OR = 1.06 per °F; p<0.001) was associated with warmer annual ambient temperatures. This finding was independently replicated in the CFF (1.02; p<0.001), ACFDR (1.05; p = 0.002), and ACFBAL (1.09; p = 0.003) subjects. Warmer temperatures (-0.34 points per °F; p = 0.005) and public insurance (-6.43 points; p<0.001) were associated with lower lung function in the CFTSS subjects. These findings were replicated in the CFF subjects (temperature: -0.31; p<0.001; insurance: -9.11; p<0.001) and similar in the ACFDR subjects (temperature: -0.23; p = 0.057). The association between temperature and lung function was minimally influenced by P. aeruginosa. Similarly, the association between temperature and P. aeruginosa was largely independent of lung function.Ambient temperature is associated with prevalence of P. aeruginosa and lung function in four independent samples of CF patients from two continents. |
url |
http://europepmc.org/articles/PMC3220679?pdf=render |
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