Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T
This single-center retrospective study was conducted to improve the early detection of local tumor progression (LTP) after irreversible electroporation (IRE) of a hepatocellular carcinoma (HCC) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-based 3T MR imaging and to...
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doaj-e5cfd6caaad64f5c8039e998cfbd0f362021-03-30T23:04:24ZengMDPI AGCancers2072-66942021-03-01131595159510.3390/cancers13071595Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3TWolf Bäumler0Philipp Wiggermann1Lukas Lürken2Marco Dollinger3Christian Stroszczynski4Lukas P. Beyer5Andreas Schicho6Department of Radiology, University Hospital Regensburg, 93042 Regensburg, GermanyDepartment of Radiology and Nuclear Medicine, Städtisches Klinikum Braunschweig, 38114 Braunschweig, GermanyDepartment of Radiology, University Hospital Regensburg, 93042 Regensburg, GermanyDepartment of Radiology, University Hospital Regensburg, 93042 Regensburg, GermanyDepartment of Radiology, University Hospital Regensburg, 93042 Regensburg, GermanyDepartment of Radiology, Klinikum Ernst von Bergmann, 14467 Potsdam, GermanyDepartment of Radiology, University Hospital Regensburg, 93042 Regensburg, GermanyThis single-center retrospective study was conducted to improve the early detection of local tumor progression (LTP) after irreversible electroporation (IRE) of a hepatocellular carcinoma (HCC) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-based 3T MR imaging and to identify helpful signal characteristics by comparing 23 patients with and 60 patients without LTP. To identify the differences in the sensitivity of MRI sequences, the specificity, positive prediction value, negative prediction value (NPV) and diagnostic odds ratio were calculated. A chi-squared test, two-tailed student’s t-test and binary logistic regression model were used to detect distinct patient characteristics and variables for the prediction of LTP. LTP was mostly detected in the peripheral ablation zone (82.6%) within the first six months (87.0%). The central LTP ablation area presented more hypointensities in T1 p.v. (sensitivity: 95.0%; NPV: 90.0%) and in T1 d.p. (sensitivity: 100.0%; NPV: 100.0) while its peripheral part showed more hyperintensities in T2 BLADE (sensitivity: 95.5%; NPV: 80.0%) and in diffusion sequences (sensitivity: 90.0%). Liver cirrhosis seems to be an unfavorable prognosticator for LTP (<i>p</i> = 0.039). In conclusion, LTP mostly occurs in the peripheral ablation zone within six months after IRE. Despite often exhibiting atypical Gd-EOB-DTPA MR signal characteristics, T2 BLADE and diffusion sequences were helpful for their detection in the peripheral zone while T1 p.v. and T1 d.p. had the highest sensitivity in the central zone.https://www.mdpi.com/2072-6694/13/7/1595irreversible electroporationhepatocellular carcinomaearly detectionmagnetic resonance imagingGd-EOB-DTPA |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Wolf Bäumler Philipp Wiggermann Lukas Lürken Marco Dollinger Christian Stroszczynski Lukas P. Beyer Andreas Schicho |
spellingShingle |
Wolf Bäumler Philipp Wiggermann Lukas Lürken Marco Dollinger Christian Stroszczynski Lukas P. Beyer Andreas Schicho Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T Cancers irreversible electroporation hepatocellular carcinoma early detection magnetic resonance imaging Gd-EOB-DTPA |
author_facet |
Wolf Bäumler Philipp Wiggermann Lukas Lürken Marco Dollinger Christian Stroszczynski Lukas P. Beyer Andreas Schicho |
author_sort |
Wolf Bäumler |
title |
Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T |
title_short |
Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T |
title_full |
Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T |
title_fullStr |
Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T |
title_full_unstemmed |
Early Detection of Local Tumor Progression after Irreversible Electroporation (IRE) of a Hepatocellular Carcinoma Using Gd-EOB-DTPA-Based MR Imaging at 3T |
title_sort |
early detection of local tumor progression after irreversible electroporation (ire) of a hepatocellular carcinoma using gd-eob-dtpa-based mr imaging at 3t |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2021-03-01 |
description |
This single-center retrospective study was conducted to improve the early detection of local tumor progression (LTP) after irreversible electroporation (IRE) of a hepatocellular carcinoma (HCC) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-based 3T MR imaging and to identify helpful signal characteristics by comparing 23 patients with and 60 patients without LTP. To identify the differences in the sensitivity of MRI sequences, the specificity, positive prediction value, negative prediction value (NPV) and diagnostic odds ratio were calculated. A chi-squared test, two-tailed student’s t-test and binary logistic regression model were used to detect distinct patient characteristics and variables for the prediction of LTP. LTP was mostly detected in the peripheral ablation zone (82.6%) within the first six months (87.0%). The central LTP ablation area presented more hypointensities in T1 p.v. (sensitivity: 95.0%; NPV: 90.0%) and in T1 d.p. (sensitivity: 100.0%; NPV: 100.0) while its peripheral part showed more hyperintensities in T2 BLADE (sensitivity: 95.5%; NPV: 80.0%) and in diffusion sequences (sensitivity: 90.0%). Liver cirrhosis seems to be an unfavorable prognosticator for LTP (<i>p</i> = 0.039). In conclusion, LTP mostly occurs in the peripheral ablation zone within six months after IRE. Despite often exhibiting atypical Gd-EOB-DTPA MR signal characteristics, T2 BLADE and diffusion sequences were helpful for their detection in the peripheral zone while T1 p.v. and T1 d.p. had the highest sensitivity in the central zone. |
topic |
irreversible electroporation hepatocellular carcinoma early detection magnetic resonance imaging Gd-EOB-DTPA |
url |
https://www.mdpi.com/2072-6694/13/7/1595 |
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