Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines

Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines

The synthesis of racemic 1,2-dioleoyl and 1-ole-oyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-dl-serine.The synthetic phosphatidyl serines wer...

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Bibliographic Details
Main Authors: D.L. Turner, M.J. Silver, E. Baczynski, N. Giordano, I. Rodalewicz
Format: Article
Language:English
Published: Elsevier 1964-10-01
Series:Journal of Lipid Research
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520401920
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spelling doaj-e5d313f5002c434eb9e13d485923704b2021-04-23T06:12:08ZengElsevierJournal of Lipid Research0022-22751964-10-0154616623Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serinesD.L. Turner0M.J. Silver1E. Baczynski2N. Giordano3I. Rodalewicz4The Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe synthesis of racemic 1,2-dioleoyl and 1-ole-oyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-dl-serine.The synthetic phosphatidyl serines were tested in blood clotting systems in vitro. They have activity qualitatively similar to that of naturally occurring phosphatidyl serines: anticoagulant activity when well solubilized and weak to moderate thromboplastic activity in simple suspension.http://www.sciencedirect.com/science/article/pii/S0022227520401920
collection DOAJ
language English
format Article
sources DOAJ
author D.L. Turner
M.J. Silver
E. Baczynski
N. Giordano
I. Rodalewicz
spellingShingle D.L. Turner
M.J. Silver
E. Baczynski
N. Giordano
I. Rodalewicz
Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
Journal of Lipid Research
author_facet D.L. Turner
M.J. Silver
E. Baczynski
N. Giordano
I. Rodalewicz
author_sort D.L. Turner
title Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
title_short Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
title_full Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
title_fullStr Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
title_full_unstemmed Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
title_sort synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
publisher Elsevier
series Journal of Lipid Research
issn 0022-2275
publishDate 1964-10-01
description The synthesis of racemic 1,2-dioleoyl and 1-ole-oyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-dl-serine.The synthetic phosphatidyl serines were tested in blood clotting systems in vitro. They have activity qualitatively similar to that of naturally occurring phosphatidyl serines: anticoagulant activity when well solubilized and weak to moderate thromboplastic activity in simple suspension.
url http://www.sciencedirect.com/science/article/pii/S0022227520401920
work_keys_str_mv AT dlturner synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines
AT mjsilver synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines
AT ebaczynski synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines
AT ngiordano synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines
AT irodalewicz synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines
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