Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines
The synthesis of racemic 1,2-dioleoyl and 1-ole-oyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-dl-serine.The synthetic phosphatidyl serines wer...
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1964-10-01
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Series: | Journal of Lipid Research |
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doaj-e5d313f5002c434eb9e13d485923704b2021-04-23T06:12:08ZengElsevierJournal of Lipid Research0022-22751964-10-0154616623Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serinesD.L. Turner0M.J. Silver1E. Baczynski2N. Giordano3I. Rodalewicz4The Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe Cardeza Foundation and Department of Pharmacology, Jefferson Medical College, Philadelphia, PennsylvaniaThe synthesis of racemic 1,2-dioleoyl and 1-ole-oyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-dl-serine.The synthetic phosphatidyl serines were tested in blood clotting systems in vitro. They have activity qualitatively similar to that of naturally occurring phosphatidyl serines: anticoagulant activity when well solubilized and weak to moderate thromboplastic activity in simple suspension.http://www.sciencedirect.com/science/article/pii/S0022227520401920 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
D.L. Turner M.J. Silver E. Baczynski N. Giordano I. Rodalewicz |
spellingShingle |
D.L. Turner M.J. Silver E. Baczynski N. Giordano I. Rodalewicz Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines Journal of Lipid Research |
author_facet |
D.L. Turner M.J. Silver E. Baczynski N. Giordano I. Rodalewicz |
author_sort |
D.L. Turner |
title |
Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines |
title_short |
Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines |
title_full |
Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines |
title_fullStr |
Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines |
title_full_unstemmed |
Synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines |
title_sort |
synthesis and activity in blood clotting systems of unsaturated racemic phosphatidyl serines |
publisher |
Elsevier |
series |
Journal of Lipid Research |
issn |
0022-2275 |
publishDate |
1964-10-01 |
description |
The synthesis of racemic 1,2-dioleoyl and 1-ole-oyl-2-stearoyl glycerol-3-phosphoryl serine was achieved by the phosphorylation of unsaturated diglycerides with phosphorus oxychloride, and combination with the phthalimidomethyl ester of carbo-t-butoxy-dl-serine.The synthetic phosphatidyl serines were tested in blood clotting systems in vitro. They have activity qualitatively similar to that of naturally occurring phosphatidyl serines: anticoagulant activity when well solubilized and weak to moderate thromboplastic activity in simple suspension. |
url |
http://www.sciencedirect.com/science/article/pii/S0022227520401920 |
work_keys_str_mv |
AT dlturner synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines AT mjsilver synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines AT ebaczynski synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines AT ngiordano synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines AT irodalewicz synthesisandactivityinbloodclottingsystemsofunsaturatedracemicphosphatidylserines |
_version_ |
1721513383320092672 |