Functional assessment of the NMDA receptor variant GluN2AR586K [version 1; referees: 1 approved, 2 approved with reservations]
Background: The N-methyl-D-aspartate receptor (NMDAR) is an ionotropic glutamate receptor that has important roles in synaptogenesis, synaptic transmission, and synaptic plasticity. Recently, a large number of rare genetic variants have been found in NMDAR subunits in people with neurodevelopmental...
Main Authors: | Katie F.M. Marwick, Peter Parker, Paul Skehel, Giles Hardingham, David J.A. Wyllie |
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Format: | Article |
Language: | English |
Published: |
Wellcome
2017-03-01
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Series: | Wellcome Open Research |
Subjects: | |
Online Access: | https://wellcomeopenresearch.org/articles/2-20/v1 |
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