The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine

A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.

Bibliographic Details
Main Authors:	Piotr Roszkowski, Jan. K. Maurin, Zbigniew Czarnocki
Format:	Article
Language:	English
Published:	Beilstein-Institut 2015-08-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	chiral diamines enantioselective reduction epinastine mianserin ruthenium complexes
Online Access:	https://doi.org/10.3762/bjoc.11.164

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spelling	doaj-e5eb73ed00134ec6b866c4895865a7c82021-03-02T10:05:00ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972015-08-011111509151310.3762/bjoc.11.1641860-5397-11-164The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastinePiotr Roszkowski0Jan. K. Maurin1Zbigniew Czarnocki2Faculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, PolandNational Medicines Institute, Chełmska 30/34, 00-725 Warsaw, Poland andFaculty of Chemistry, University of Warsaw, Pasteura 1, 02-093, Warsaw, PolandA simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.https://doi.org/10.3762/bjoc.11.164chiral diaminesenantioselective reductionepinastinemianserinruthenium complexes
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Piotr Roszkowski Jan. K. Maurin Zbigniew Czarnocki
spellingShingle	Piotr Roszkowski Jan. K. Maurin Zbigniew Czarnocki The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine Beilstein Journal of Organic Chemistry chiral diamines enantioselective reduction epinastine mianserin ruthenium complexes
author_facet	Piotr Roszkowski Jan. K. Maurin Zbigniew Czarnocki
author_sort	Piotr Roszkowski
title	The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_short	The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_full	The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_fullStr	The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_full_unstemmed	The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine
title_sort	enantioselective synthesis of (s)-(+)-mianserin and (s)-(+)-epinastine
publisher	Beilstein-Institut
series	Beilstein Journal of Organic Chemistry
issn	1860-5397
publishDate	2015-08-01
description	A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.
topic	chiral diamines enantioselective reduction epinastine mianserin ruthenium complexes
url	https://doi.org/10.3762/bjoc.11.164
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The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine

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