The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine

The enantioselective synthesis of (S)-(+)-mianserin and (S)-(+)-epinastine

A simple enantioselective synthetic procedure for the preparation of mianserin and epinastine in optically pure form is described. The key step in the synthetic pathway is the asymmetric reduction of the cyclic imine using asymmetric transfer hydrogenation conditions.

Bibliographic Details
Main Authors: Piotr Roszkowski, Jan. K. Maurin, Zbigniew Czarnocki
Format: Article
Language:English
Published: Beilstein-Institut 2015-08-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
chiral diamines
enantioselective reduction
epinastine
mianserin
ruthenium complexes
Online Access:https://doi.org/10.3762/bjoc.11.164

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