Intracerebral delivery of Carboplatin in combination with either 6 MV Photons or monoenergetic synchrotron X-rays are equally efficacious for treatment of the F98 rat glioma

• Main Authors: Bobyk Laure, Edouard Magali, Deman Pierre, Rousseau Julia, Adam Jean-François, Ravanat Jean-Luc, Estève François, Balosso Jacques, Barth Rolf F, Elleaume Hélène
• Format: Article
• Language: English
• Published: BMC 2012-09-01
• Series: Journal of Experimental & Clinical Cancer Research
• Subjects: F98 rat glioma; Carboplatin; Osmotic pumps; Intracerebral delivery; Radiotherapy with 6 MV photons or synchrotron X-rays
• Online Access: http://www.jeccr.com/content/31/1/78

<p>Abstract</p> <p>Background</p> <p>The purpose of the present study was to compare side-by-side the therapeutic efficacy of a 6-day infusion of carboplatin, followed by X-irradiation with either 6 MV photons or synchrotron X-rays, tuned above the K-edge of Pt, for treatment of F98 glioma bearing rats.</p> <p>Methods</p> <p>Carboplatin was administered intracerebrally (i.c.) to F98 glioma bearing rats over 6 days using Alzet^TM osmotic pumps starting 7 days after tumor implantation. Radiotherapy was delivered in a single 15 Gy fraction on day 14 using a conventional 6 MV linear accelerator (LINAC) or 78.8 keV synchrotron X-rays.</p> <p>Results</p> <p>Untreated control animals had a median survival time (MeST) of 33 days. Animals that received either carboplatin alone or irradiation alone with either 78.8 keV or 6 MV had a MeSTs 38 and 33 days, respectively. Animals that received carboplatin in combination with X-irradiation had a MeST of > 180 days with a 55% cure rate, irrespective of whether they were irradiated with either 78.8 KeV synchrotron X-rays or 6MV photons.</p> <p>Conclusions</p> <p>These studies have conclusively demonstrated the equivalency of i.c. delivery of carboplatin in combination with X-irradiation with either 6 MV photons or synchrotron X-rays.</p>