Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection
Abstract Hepatitis E virus (HEV) as an emerging zoonotic pathogen causes a major public health issue. Transmission from domestic, wildlife and zoo animals to human has been widely reported. Whether pets also serve as reservoirs remains an intriguing question. In this study, we found the sero-positiv...
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doaj-e5fda4415dfe41d5bd13d11750f5b3862020-11-25T01:31:37ZengBMCIrish Veterinary Journal2046-04812020-04-017311510.1186/s13620-020-00158-yHepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infectionYunlong Li0Changbo Qu1Bart Spee2Ruyi Zhang3Louis C. Penning4Robert A. de Man5Maikel P. Peppelenbosch6Hille Fieten7Qiuwei Pan8Department of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterDepartment of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Gastroenterology and Hepatology, Erasmus MC-University Medical CenterAbstract Hepatitis E virus (HEV) as an emerging zoonotic pathogen causes a major public health issue. Transmission from domestic, wildlife and zoo animals to human has been widely reported. Whether pets also serve as reservoirs remains an intriguing question. In this study, we found the sero-positive rates of HEV-specific antibodies in pet dogs, cats and horses of 18.52% (30/162), 14.89% (7/47) and 18.18% (4/22) in the Netherlands. Although HEV viral RNA was not detected in these animals, we have demonstrated that dog liver cells are susceptible to HEV infection in vitro. These results call more attention to address the potential role of pets in the zoonotic transmission of HEV.http://link.springer.com/article/10.1186/s13620-020-00158-yHEVDogCatHorseSeroprevalenceInfection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Yunlong Li Changbo Qu Bart Spee Ruyi Zhang Louis C. Penning Robert A. de Man Maikel P. Peppelenbosch Hille Fieten Qiuwei Pan |
spellingShingle |
Yunlong Li Changbo Qu Bart Spee Ruyi Zhang Louis C. Penning Robert A. de Man Maikel P. Peppelenbosch Hille Fieten Qiuwei Pan Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection Irish Veterinary Journal HEV Dog Cat Horse Seroprevalence Infection |
author_facet |
Yunlong Li Changbo Qu Bart Spee Ruyi Zhang Louis C. Penning Robert A. de Man Maikel P. Peppelenbosch Hille Fieten Qiuwei Pan |
author_sort |
Yunlong Li |
title |
Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection |
title_short |
Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection |
title_full |
Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection |
title_fullStr |
Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection |
title_full_unstemmed |
Hepatitis E virus seroprevalence in pets in the Netherlands and the permissiveness of canine liver cells to the infection |
title_sort |
hepatitis e virus seroprevalence in pets in the netherlands and the permissiveness of canine liver cells to the infection |
publisher |
BMC |
series |
Irish Veterinary Journal |
issn |
2046-0481 |
publishDate |
2020-04-01 |
description |
Abstract Hepatitis E virus (HEV) as an emerging zoonotic pathogen causes a major public health issue. Transmission from domestic, wildlife and zoo animals to human has been widely reported. Whether pets also serve as reservoirs remains an intriguing question. In this study, we found the sero-positive rates of HEV-specific antibodies in pet dogs, cats and horses of 18.52% (30/162), 14.89% (7/47) and 18.18% (4/22) in the Netherlands. Although HEV viral RNA was not detected in these animals, we have demonstrated that dog liver cells are susceptible to HEV infection in vitro. These results call more attention to address the potential role of pets in the zoonotic transmission of HEV. |
topic |
HEV Dog Cat Horse Seroprevalence Infection |
url |
http://link.springer.com/article/10.1186/s13620-020-00158-y |
work_keys_str_mv |
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