In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells

In the presence of TGF-β1, Asperosaponin VI promotes human mesenchymal stem cell differentiation into nucleus pulposus like- cells

Abstract Background The regeneration of nucleus pulposus (NP) cells is an effective method to prevent intervertebral disc degeneration (IVDD). In this study, we investigated the role of Asperosaponin VI (ASA VI), isolated from a traditional Chinese medicine (TCM), the root of Dipsacus asper Wall, in...

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Bibliographic Details
Main Authors: Yong-tao Niu, Lin Xie, Rong-Rong Deng, Xiao-yu Zhang
Format: Article
Language:English
Published: BMC 2021-01-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Asperosaponin VI
Human mesenchymal stem cell
Differentiation
Nucleus pulposus-like cell
ERK1/2
smad2/3
Online Access:https://doi.org/10.1186/s12906-020-03169-y

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