Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients
Objective: To compare the levels of p38 mitogen-activated protein kinase (MAPK), soluble endoglin and endothelin-1 in the serum of patients with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and normal pregnancies. Methods: This study was an observational...
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Wolters Kluwer Medknow Publications
2019-01-01
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doaj-e6151a9feede4ddebc27a24743fc1f3f2020-11-25T02:26:30ZengWolters Kluwer Medknow PublicationsAsian Pacific Journal of Reproduction2305-05002305-05192019-01-0182838710.4103/2305-0500.254650Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patientsEfendi LukasMaisuri T ChalidUpik A MiskadSyakib BakriObjective: To compare the levels of p38 mitogen-activated protein kinase (MAPK), soluble endoglin and endothelin-1 in the serum of patients with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and normal pregnancies. Methods: This study was an observational analytic cross-sectional study performed at Wahidin Sudirohusodo Hospital, Makassar, Indonesia, in the period of 5th February 2016 to 20th January 2017. P38 MAPK, soluble endoglin and endothelin-1 levels of patients with normal pregnancies, severe preeclampsia and HELLP syndrome were measured by enzyme-linked immunoabsorbentassay technique, using kits of human soluble endoglin, endothelin-1 and p38 MAPK, Quantikine immunoassay: R&D System Inc. Results: Level of serum p38 MAPK in HELLP syndrome group was higher than in severe preeclampsia and normal pregnancy groups. Soluble endoglin and endothelin-1 levels in pregnancies with severe preeclampsia and HELLP syndrome were higher than normal pregnancy but there was no significant difference between these two groups (P>0.05). Levels of p38 MAPK, soluble endoglin and endothelin-1 also had a positive linear correlation with systolic and diastolic blood pressures (P<0.05). Conclusions: P38 MAPK in serum may be a marker for evidence of the severe hypoxia and its application may be considered for the diagnosis of HELLP syndrome.http://www.apjr.net/article.asp?issn=2305-0500;year=2019;volume=8;issue=2;spage=83;epage=87;aulast=LukasPreeclampsiaHELLP syndromep38 MAPKSoluble endoglinEndothelin-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Efendi Lukas Maisuri T Chalid Upik A Miskad Syakib Bakri |
spellingShingle |
Efendi Lukas Maisuri T Chalid Upik A Miskad Syakib Bakri Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients Asian Pacific Journal of Reproduction Preeclampsia HELLP syndrome p38 MAPK Soluble endoglin Endothelin-1 |
author_facet |
Efendi Lukas Maisuri T Chalid Upik A Miskad Syakib Bakri |
author_sort |
Efendi Lukas |
title |
Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients |
title_short |
Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients |
title_full |
Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients |
title_fullStr |
Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients |
title_full_unstemmed |
Comparison of p38 MAPK, soluble endoglin and endothelin-1 level in severe preeclampsia and HELLP syndrome patients |
title_sort |
comparison of p38 mapk, soluble endoglin and endothelin-1 level in severe preeclampsia and hellp syndrome patients |
publisher |
Wolters Kluwer Medknow Publications |
series |
Asian Pacific Journal of Reproduction |
issn |
2305-0500 2305-0519 |
publishDate |
2019-01-01 |
description |
Objective: To compare the levels of p38 mitogen-activated protein kinase (MAPK), soluble endoglin and endothelin-1 in the serum of patients with severe preeclampsia, hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and normal pregnancies.
Methods: This study was an observational analytic cross-sectional study performed at Wahidin Sudirohusodo Hospital, Makassar, Indonesia, in the period of 5th February 2016 to 20th January 2017. P38 MAPK, soluble endoglin and endothelin-1 levels of patients with normal pregnancies, severe preeclampsia and HELLP syndrome were measured by enzyme-linked immunoabsorbentassay technique, using kits of human soluble endoglin, endothelin-1 and p38 MAPK, Quantikine immunoassay: R&D System Inc.
Results: Level of serum p38 MAPK in HELLP syndrome group was higher than in severe preeclampsia and normal pregnancy groups. Soluble endoglin and endothelin-1 levels in pregnancies with severe preeclampsia and HELLP syndrome were higher than normal pregnancy but there was no significant difference between these two groups (P>0.05). Levels of p38 MAPK, soluble endoglin and endothelin-1 also had a positive linear correlation with systolic and diastolic blood pressures (P<0.05).
Conclusions: P38 MAPK in serum may be a marker for evidence of the severe hypoxia and its application may be considered for the diagnosis of HELLP syndrome. |
topic |
Preeclampsia HELLP syndrome p38 MAPK Soluble endoglin Endothelin-1 |
url |
http://www.apjr.net/article.asp?issn=2305-0500;year=2019;volume=8;issue=2;spage=83;epage=87;aulast=Lukas |
work_keys_str_mv |
AT efendilukas comparisonofp38mapksolubleendoglinandendothelin1levelinseverepreeclampsiaandhellpsyndromepatients AT maisuritchalid comparisonofp38mapksolubleendoglinandendothelin1levelinseverepreeclampsiaandhellpsyndromepatients AT upikamiskad comparisonofp38mapksolubleendoglinandendothelin1levelinseverepreeclampsiaandhellpsyndromepatients AT syakibbakri comparisonofp38mapksolubleendoglinandendothelin1levelinseverepreeclampsiaandhellpsyndromepatients |
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