The Roles of MicroRNAs in Breast Cancer
MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22 nucleotide, non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Accumulating lines of evidence have indicated that miRNAs play important roles in the maintenance of biologi...
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doaj-e615415275f0483893a1c606c0a603f32020-11-24T23:27:08ZengMDPI AGCancers2072-66942015-04-017259861610.3390/cancers7020598cancers7020598The Roles of MicroRNAs in Breast CancerRyou-u Takahashi0Hiroaki Miyazaki1Takahiro Ochiya2Division of Molecular and Cellular Medicine, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, JapanDivision of Molecular and Cellular Medicine, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, JapanDivision of Molecular and Cellular Medicine, National Cancer Center Research Institute 1-1, Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, JapanMicroRNAs (miRNAs) constitute a large family of small, approximately 20–22 nucleotide, non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Accumulating lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are associated with the onset of many diseases, including cancer. In various cancers, miRNAs play important roles in tumor initiation, drug resistance and metastasis. Recent studies reported that miRNAs could also be secreted via small endosome-derived vesicles called exosomes, which are derived from multiple cell types, including dendritic cells, lymphocytes, and tumor cells. Exosomal miRNAs play an important role in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers. In this review, we summarize the major findings related to the functions of miRNAs in breast cancer, which is the most frequent cancer in women, and discuss the potential clinical uses of miRNAs, including their roles as therapeutic targets and diagnostic markers.http://www.mdpi.com/2072-6694/7/2/598microRNAtherapydiagnosisbreast cancer |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ryou-u Takahashi Hiroaki Miyazaki Takahiro Ochiya |
spellingShingle |
Ryou-u Takahashi Hiroaki Miyazaki Takahiro Ochiya The Roles of MicroRNAs in Breast Cancer Cancers microRNA therapy diagnosis breast cancer |
author_facet |
Ryou-u Takahashi Hiroaki Miyazaki Takahiro Ochiya |
author_sort |
Ryou-u Takahashi |
title |
The Roles of MicroRNAs in Breast Cancer |
title_short |
The Roles of MicroRNAs in Breast Cancer |
title_full |
The Roles of MicroRNAs in Breast Cancer |
title_fullStr |
The Roles of MicroRNAs in Breast Cancer |
title_full_unstemmed |
The Roles of MicroRNAs in Breast Cancer |
title_sort |
roles of micrornas in breast cancer |
publisher |
MDPI AG |
series |
Cancers |
issn |
2072-6694 |
publishDate |
2015-04-01 |
description |
MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22 nucleotide, non-coding RNAs that regulate the expression of target genes, mainly at the post-transcriptional level. Accumulating lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are associated with the onset of many diseases, including cancer. In various cancers, miRNAs play important roles in tumor initiation, drug resistance and metastasis. Recent studies reported that miRNAs could also be secreted via small endosome-derived vesicles called exosomes, which are derived from multiple cell types, including dendritic cells, lymphocytes, and tumor cells. Exosomal miRNAs play an important role in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers. In this review, we summarize the major findings related to the functions of miRNAs in breast cancer, which is the most frequent cancer in women, and discuss the potential clinical uses of miRNAs, including their roles as therapeutic targets and diagnostic markers. |
topic |
microRNA therapy diagnosis breast cancer |
url |
http://www.mdpi.com/2072-6694/7/2/598 |
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