Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation
A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that “the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy”. However, a relation...
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The Company of Biologists
2012-09-01
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Series: | Disease Models & Mechanisms |
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doaj-e61730038fbf4b839cf9ffe2ae1aa4772020-11-25T01:23:34ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112012-09-015560861310.1242/dmm.009837009837Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulationJohn E. BlundellPhillipa CaudwellCatherine GibbonsMark HopkinsErik NaslundNeil KingGraham FinlaysonA long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that “the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy”. However, a relationship between energy expenditure and energy intake within any one day could not be found, although there was a correlation over 2 weeks. This issue was never resolved before interest in integrative biology was replaced by molecular biochemistry. Using a psychobiological approach, we have studied appetite control in an energy balance framework using a multi-level experimental system on a single cohort of overweight and obese human subjects. This has disclosed relationships between variables in the domains of body composition [fat-free mass (FFM), fat mass (FM)], metabolism, gastrointestinal hormones, hunger and energy intake. In this Commentary, we review our own and other data, and discuss a new formulation whereby appetite control and energy intake are regulated by energy expenditure. Specifically, we propose that FFM (the largest contributor to resting metabolic rate), but not body mass index or FM, is closely associated with self-determined meal size and daily energy intake. This formulation has implications for understanding weight regulation and the management of obesity.http://dmm.biologists.org/content/5/5/608 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
John E. Blundell Phillipa Caudwell Catherine Gibbons Mark Hopkins Erik Naslund Neil King Graham Finlayson |
spellingShingle |
John E. Blundell Phillipa Caudwell Catherine Gibbons Mark Hopkins Erik Naslund Neil King Graham Finlayson Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation Disease Models & Mechanisms |
author_facet |
John E. Blundell Phillipa Caudwell Catherine Gibbons Mark Hopkins Erik Naslund Neil King Graham Finlayson |
author_sort |
John E. Blundell |
title |
Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation |
title_short |
Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation |
title_full |
Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation |
title_fullStr |
Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation |
title_full_unstemmed |
Role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation |
title_sort |
role of resting metabolic rate and energy expenditure in hunger and appetite control: a new formulation |
publisher |
The Company of Biologists |
series |
Disease Models & Mechanisms |
issn |
1754-8403 1754-8411 |
publishDate |
2012-09-01 |
description |
A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that “the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy”. However, a relationship between energy expenditure and energy intake within any one day could not be found, although there was a correlation over 2 weeks. This issue was never resolved before interest in integrative biology was replaced by molecular biochemistry. Using a psychobiological approach, we have studied appetite control in an energy balance framework using a multi-level experimental system on a single cohort of overweight and obese human subjects. This has disclosed relationships between variables in the domains of body composition [fat-free mass (FFM), fat mass (FM)], metabolism, gastrointestinal hormones, hunger and energy intake. In this Commentary, we review our own and other data, and discuss a new formulation whereby appetite control and energy intake are regulated by energy expenditure. Specifically, we propose that FFM (the largest contributor to resting metabolic rate), but not body mass index or FM, is closely associated with self-determined meal size and daily energy intake. This formulation has implications for understanding weight regulation and the management of obesity. |
url |
http://dmm.biologists.org/content/5/5/608 |
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