Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy
Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo- and radiotherapeutics increases the effectiveness of the therapy and reduces the...
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doaj-e61a87dfced64903a2b7a8ba356738d92020-11-25T02:12:25ZengAIP Publishing LLCAPL Materials2166-532X2014-11-01211113315113315-1310.1063/1.4899118014493APMChemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapyImalka Munaweera0Bhuvaneswari Koneru1Yi Shi2Anthony J. Di Pasqua3Kenneth J. Balkus, Jr.4Department of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, Texas 75080, USADepartment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, Texas 76107, USADepartment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, Texas 76107, USADepartment of Pharmaceutical Sciences, University of North Texas System College of Pharmacy, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, Texas 76107, USADepartment of Chemistry, University of Texas at Dallas, 800 West Campbell Rd., Richardson, Texas 75080, USA Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo- and radiotherapeutics increases the effectiveness of the therapy and reduces the dosage of each individual drug required to produce an observable therapeutic response. We here developed a novel chemoradiotherapeutic 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid coated/uncoated platinum drug loaded, holmium-containing, wrinkled mesoporous silica nanoparticle. The materials were characterized with TEM, FTIR, 1H NMR, energy dispersive x-ray, inductively coupled plasma-mass spectrometry, and zeta potential measurements. In vitro platinum drug release from both lipid coated and uncoated chemoradiotherapeutic wrinkled mesoporous silica are reported. Various kinetic models were used to analyze the release kinetics. The radioactivity of the chemoradiotherapeutic nanocarriers was measured after neutron-activation. http://dx.doi.org/10.1063/1.4899118 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Imalka Munaweera Bhuvaneswari Koneru Yi Shi Anthony J. Di Pasqua Kenneth J. Balkus, Jr. |
spellingShingle |
Imalka Munaweera Bhuvaneswari Koneru Yi Shi Anthony J. Di Pasqua Kenneth J. Balkus, Jr. Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy APL Materials |
author_facet |
Imalka Munaweera Bhuvaneswari Koneru Yi Shi Anthony J. Di Pasqua Kenneth J. Balkus, Jr. |
author_sort |
Imalka Munaweera |
title |
Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy |
title_short |
Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy |
title_full |
Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy |
title_fullStr |
Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy |
title_full_unstemmed |
Chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy |
title_sort |
chemoradiotherapeutic wrinkled mesoporous silica nanoparticles for use in cancer therapy |
publisher |
AIP Publishing LLC |
series |
APL Materials |
issn |
2166-532X |
publishDate |
2014-11-01 |
description |
Over the last decade, the development and application of nanotechnology in cancer detection, diagnosis, and therapy have been widely reported. Engineering of vehicles for the simultaneous delivery of chemo- and radiotherapeutics increases the effectiveness of the therapy and reduces the dosage of each individual drug required to produce an observable therapeutic response. We here developed a novel chemoradiotherapeutic 1,2-dioleoyl-sn-glycero-3-phosphocholine lipid coated/uncoated platinum drug loaded, holmium-containing, wrinkled mesoporous silica nanoparticle. The materials were characterized with TEM, FTIR, 1H NMR, energy dispersive x-ray, inductively coupled plasma-mass spectrometry, and zeta potential measurements. In vitro platinum drug release from both lipid coated and uncoated chemoradiotherapeutic wrinkled mesoporous silica are reported. Various kinetic models were used to analyze the release kinetics. The radioactivity of the chemoradiotherapeutic nanocarriers was measured after neutron-activation.
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url |
http://dx.doi.org/10.1063/1.4899118 |
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