Development of Dual Drug Loaded Nanosized Liposomal Formulation by A Reengineered Ethanolic Injection Method and Its Pre-Clinical Pharmacokinetic Studies

Development of Dual Drug Loaded Nanosized Liposomal Formulation by A Reengineered Ethanolic Injection Method and Its Pre-Clinical Pharmacokinetic Studies

Oleanolic acid (OA), which is a natural pentacyclic terpenoid, has been identified for hepato-protective, nephron-protective and cardio-tonic properties. In contrast, doxorubicin (DOX) is a famous anti-cancer drug but its efficacy is a question mark because of its known cardio-toxicity. We developed...

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Bibliographic Details
Main Authors: Muhammad Sarfraz, Attia Afzal, Tan Yang, Yongkang Gai, Shahid Masood Raza, Muhammad Waseem Khan, Yao Cheng, Xiang Ma, Guangya Xiang
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Pharmaceutics
Subjects:
oleanolic acid
doxorubicin
pegylated liposomes
reengineered ethanolic injection method
cardiotoxicity
Online Access:http://www.mdpi.com/1999-4923/10/3/151

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