Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival
Background and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children represents a high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanic populations, in which it is a rare malignancy. We report the characteristics and results of treatment for childhood...
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doaj-e61e0965e61f4230b1033fdfd8151ab22020-11-25T03:52:17ZengElsevierHematology, Transfusion and Cell Therapy2531-13792020-10-01424320325Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survivalJosé Carlos Jaime-Pérez0José Antonio Hernández-de los Santos1David Gómez-Almaguer2Corresponding author at: Servicio de Hematología. Edificio Dr. Rodrigo Barragán, 2° piso, Hospital Universitario Dr. José E. González, Avenida Madero y Gonzalitos s/n, Colonia Mitras Centro, Monterrey, N. L., Mexico.; Universidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario Dr. José Eleuterio González, Monterry, MexicoUniversidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario Dr. José Eleuterio González, Monterry, MexicoUniversidad Autónoma de Nuevo León, Facultad de Medicina y Hospital Universitario Dr. José Eleuterio González, Monterry, MexicoBackground and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children represents a high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanic populations, in which it is a rare malignancy. We report the characteristics and results of treatment for childhood T-cell ALL in children over 14 years at a Latin American reference center. Material and methods: From January 2005 to December 2018, there occurred the analysis of twenty patients ≤ 16 years of age from a low-income open population diagnosed at a university hospital in Northeast Mexico. Clinical and laboratory characteristics, treatment regimens and outcomes were assessed by scrutinizing clinical records and electronic databases. Diagnosis was confirmed by flow cytometry, including positivity for CD-2, 5, 7 and surface/cytoplasmic CD3. Survival rates were assessed by the Kaplan-Meier method. Results: There was a male preponderance (70 %), with a 2.3 male-to-female ratio (p = .074), the median age being 9.5 years. Leucocytes at diagnosis were ≥ 50 × 109/L in 13 (65 %) children, with CNS infiltration in 6 (30 %) and organomegaly in 10 (50 %). The five-year overall survival (OS) was 44.3 % (95 % CI 41.96–46.62), significantly lower in girls, at 20.8 % (95 % CI 17.32–24.51) vs. 53.1 % (95 % CI 50.30–55.82), (p = .035) in boys; there was no sex difference in the event-free survival (EFS) (p = .215). The survival was significantly higher after 2010 (p = .034). Conclusion: The T-cell ALL was more frequent in boys, had a higher mortality in girls and the survival has increased over the last decade with improved chemotherapy and supportive care.http://www.sciencedirect.com/science/article/pii/S2531137919301646T-cell acute lymphoblastic leukemiaT-ALLALL immunophenotypeALL sex distribution |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
José Carlos Jaime-Pérez José Antonio Hernández-de los Santos David Gómez-Almaguer |
spellingShingle |
José Carlos Jaime-Pérez José Antonio Hernández-de los Santos David Gómez-Almaguer Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival Hematology, Transfusion and Cell Therapy T-cell acute lymphoblastic leukemia T-ALL ALL immunophenotype ALL sex distribution |
author_facet |
José Carlos Jaime-Pérez José Antonio Hernández-de los Santos David Gómez-Almaguer |
author_sort |
José Carlos Jaime-Pérez |
title |
Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
title_short |
Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
title_full |
Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
title_fullStr |
Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
title_full_unstemmed |
Childhood T-cell acute lymphoblastic leukemia in a single Latin American center: impact of improved treatment scheme and support therapy on survival |
title_sort |
childhood t-cell acute lymphoblastic leukemia in a single latin american center: impact of improved treatment scheme and support therapy on survival |
publisher |
Elsevier |
series |
Hematology, Transfusion and Cell Therapy |
issn |
2531-1379 |
publishDate |
2020-10-01 |
description |
Background and objective: T-cell acute lymphoblastic leukemia (T-ALL) in children represents a high-risk disease. There is a lack of studies assessing the outcome of T-ALL in Hispanic populations, in which it is a rare malignancy. We report the characteristics and results of treatment for childhood T-cell ALL in children over 14 years at a Latin American reference center. Material and methods: From January 2005 to December 2018, there occurred the analysis of twenty patients ≤ 16 years of age from a low-income open population diagnosed at a university hospital in Northeast Mexico. Clinical and laboratory characteristics, treatment regimens and outcomes were assessed by scrutinizing clinical records and electronic databases. Diagnosis was confirmed by flow cytometry, including positivity for CD-2, 5, 7 and surface/cytoplasmic CD3. Survival rates were assessed by the Kaplan-Meier method. Results: There was a male preponderance (70 %), with a 2.3 male-to-female ratio (p = .074), the median age being 9.5 years. Leucocytes at diagnosis were ≥ 50 × 109/L in 13 (65 %) children, with CNS infiltration in 6 (30 %) and organomegaly in 10 (50 %). The five-year overall survival (OS) was 44.3 % (95 % CI 41.96–46.62), significantly lower in girls, at 20.8 % (95 % CI 17.32–24.51) vs. 53.1 % (95 % CI 50.30–55.82), (p = .035) in boys; there was no sex difference in the event-free survival (EFS) (p = .215). The survival was significantly higher after 2010 (p = .034). Conclusion: The T-cell ALL was more frequent in boys, had a higher mortality in girls and the survival has increased over the last decade with improved chemotherapy and supportive care. |
topic |
T-cell acute lymphoblastic leukemia T-ALL ALL immunophenotype ALL sex distribution |
url |
http://www.sciencedirect.com/science/article/pii/S2531137919301646 |
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