Statins everyday versus alternate days: Is there a difference in myalgia rates?
Objective: Statins are widely used drugs, known to cause myalgia, leading to high discontinuation rates. The objective of our study was to determine the frequency of myalgia in patients on everyday-dose (EDD) regimen with those on alternate-day dose (ADD) regimen. Methods: This cross sectional study...
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doaj-e627c0dbdf794cc2969fe8546f97b9962020-11-25T00:54:28ZengElsevierIndian Heart Journal0019-48322018-07-01704492496Statins everyday versus alternate days: Is there a difference in myalgia rates?Ramsha Riaz0Aleena Zehra Merchant1Muhammad Salman Ul Haq2Syed Ali Raza Nasir3Yusra Rizvi4Jehanzeb Ahmed Khan5Sara Mohiuddin Zakaria6Hassaan Jawed7Khizar Hamid8Noor-ul-ain Zehra9Madiha Ahmed10Hussain Asif Ali11Kaneez Fatima12Dow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanCorresponding author at: A-110, Main Khayaban-e-Muhafiz, Phase 6 DHA, 75500, Karachi, Pakistan.; Dow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanDow Medical College, Dow university of Health Sciences, Karachi, PakistanObjective: Statins are widely used drugs, known to cause myalgia, leading to high discontinuation rates. The objective of our study was to determine the frequency of myalgia in patients on everyday-dose (EDD) regimen with those on alternate-day dose (ADD) regimen. Methods: This cross sectional study was conducted in a tertiary care hospital of Pakistan. A sample size of 400 patients between the age of 40–70 years, taking simvastatin 40 mg for at least 6 months or more were selected. Patients with prior musculoskeletal or neuromuscular complains, and family history of muscular disorders were excluded. Subjects were evaluated for myalgia via a self-administered questionnaire, and those complaining of myalgia were then evaluated for serum vitamin D levels. Data was analyzed through SPSS 16.0 and compared using chi square test. Results: The overall prevalence of myalgia was 7% (28/400). Frequency of myalgia in patients taking simvastatin everyday (n = 20, 10%) was significantly higher compared to those taking it every alternate day (n = 8, 4%) (p = 0.02). There was no significant difference between the time of onset, nature, severity, type, or location of myalgia between the 2 groups. The most common cited triggering factor for pain was physical exercise. Of the patients experiencing myalgia, 13 (6.5%) from the EDD group and 6 (3%) from the ADD group had low levels of vitamin D. Conclusions: ADD regime was better tolerated by the patients than EDD regime. Alternate day therapy, with or without vitamin D supplementation, may be used by the physicians for troublesome muscular complains. Keywords: Alternate-day dosage, Everyday dosage, Myalgia, Simvastatin, Statinhttp://www.sciencedirect.com/science/article/pii/S0019483217300482 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ramsha Riaz Aleena Zehra Merchant Muhammad Salman Ul Haq Syed Ali Raza Nasir Yusra Rizvi Jehanzeb Ahmed Khan Sara Mohiuddin Zakaria Hassaan Jawed Khizar Hamid Noor-ul-ain Zehra Madiha Ahmed Hussain Asif Ali Kaneez Fatima |
spellingShingle |
Ramsha Riaz Aleena Zehra Merchant Muhammad Salman Ul Haq Syed Ali Raza Nasir Yusra Rizvi Jehanzeb Ahmed Khan Sara Mohiuddin Zakaria Hassaan Jawed Khizar Hamid Noor-ul-ain Zehra Madiha Ahmed Hussain Asif Ali Kaneez Fatima Statins everyday versus alternate days: Is there a difference in myalgia rates? Indian Heart Journal |
author_facet |
Ramsha Riaz Aleena Zehra Merchant Muhammad Salman Ul Haq Syed Ali Raza Nasir Yusra Rizvi Jehanzeb Ahmed Khan Sara Mohiuddin Zakaria Hassaan Jawed Khizar Hamid Noor-ul-ain Zehra Madiha Ahmed Hussain Asif Ali Kaneez Fatima |
author_sort |
Ramsha Riaz |
title |
Statins everyday versus alternate days: Is there a difference in myalgia rates? |
title_short |
Statins everyday versus alternate days: Is there a difference in myalgia rates? |
title_full |
Statins everyday versus alternate days: Is there a difference in myalgia rates? |
title_fullStr |
Statins everyday versus alternate days: Is there a difference in myalgia rates? |
title_full_unstemmed |
Statins everyday versus alternate days: Is there a difference in myalgia rates? |
title_sort |
statins everyday versus alternate days: is there a difference in myalgia rates? |
publisher |
Elsevier |
series |
Indian Heart Journal |
issn |
0019-4832 |
publishDate |
2018-07-01 |
description |
Objective: Statins are widely used drugs, known to cause myalgia, leading to high discontinuation rates. The objective of our study was to determine the frequency of myalgia in patients on everyday-dose (EDD) regimen with those on alternate-day dose (ADD) regimen. Methods: This cross sectional study was conducted in a tertiary care hospital of Pakistan. A sample size of 400 patients between the age of 40–70 years, taking simvastatin 40 mg for at least 6 months or more were selected. Patients with prior musculoskeletal or neuromuscular complains, and family history of muscular disorders were excluded. Subjects were evaluated for myalgia via a self-administered questionnaire, and those complaining of myalgia were then evaluated for serum vitamin D levels. Data was analyzed through SPSS 16.0 and compared using chi square test. Results: The overall prevalence of myalgia was 7% (28/400). Frequency of myalgia in patients taking simvastatin everyday (n = 20, 10%) was significantly higher compared to those taking it every alternate day (n = 8, 4%) (p = 0.02). There was no significant difference between the time of onset, nature, severity, type, or location of myalgia between the 2 groups. The most common cited triggering factor for pain was physical exercise. Of the patients experiencing myalgia, 13 (6.5%) from the EDD group and 6 (3%) from the ADD group had low levels of vitamin D. Conclusions: ADD regime was better tolerated by the patients than EDD regime. Alternate day therapy, with or without vitamin D supplementation, may be used by the physicians for troublesome muscular complains. Keywords: Alternate-day dosage, Everyday dosage, Myalgia, Simvastatin, Statin |
url |
http://www.sciencedirect.com/science/article/pii/S0019483217300482 |
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