Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipients
Abstract The prognostic significance of suPAR in various kidney diseases has recently been demonstrated. Its role in transplantation-specific outcomes is still largely unknown. Therefore, we prospectively investigated the prognostic relevance of suPAR in patients before and one year after kidney tra...
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2021-02-01
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Online Access: | https://doi.org/10.1038/s41598-021-83333-7 |
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doaj-e62d14c484ec41609568db3146fc28932021-02-14T12:36:31ZengNature Publishing GroupScientific Reports2045-23222021-02-011111910.1038/s41598-021-83333-7Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipientsUlrich Jehn0Katharina Schütte-Nütgen1Ute Henke2Hermann Pavenstädt3Barbara Suwelack4Stefan Reuter5Division of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of MuensterDivision of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of MuensterDivision of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of MuensterDivision of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of MuensterDivision of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of MuensterDivision of General Internal Medicine, Nephrology and Rheumatology, Department of Medicine D, University Hospital of MuensterAbstract The prognostic significance of suPAR in various kidney diseases has recently been demonstrated. Its role in transplantation-specific outcomes is still largely unknown. Therefore, we prospectively investigated the prognostic relevance of suPAR in patients before and one year after kidney transplantation (KTx). We included 100 patients who had received a kidney transplantation between 2013 and 2015. The plasma concentration of suPAR was measured by ELISA assay. In recipients of living donations (LD), pre-transplant suPAR levels were significantly lower than those of recipients of deceased donations (DD). After KTx, suPAR levels significantly declined in LD and DD recipients, without a detectable difference between both groups any more. Higher suPAR levels in recipients one year after KTx were associated with a more severe eGFR loss in the following three years in multivariable cox-regression (n = 82, p = 0.021). suPAR-levels above 6212 pg/ml one year after KTx are associated with eGFR loss > 30%, which occurred almost twice as fast as in patients with suPAR ≤ 6212 pg/ml (p < 0.001). Hence, suPAR level at one year mark might be a risk indicator of increased eGFR loss.https://doi.org/10.1038/s41598-021-83333-7 |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ulrich Jehn Katharina Schütte-Nütgen Ute Henke Hermann Pavenstädt Barbara Suwelack Stefan Reuter |
spellingShingle |
Ulrich Jehn Katharina Schütte-Nütgen Ute Henke Hermann Pavenstädt Barbara Suwelack Stefan Reuter Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipients Scientific Reports |
author_facet |
Ulrich Jehn Katharina Schütte-Nütgen Ute Henke Hermann Pavenstädt Barbara Suwelack Stefan Reuter |
author_sort |
Ulrich Jehn |
title |
Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipients |
title_short |
Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipients |
title_full |
Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipients |
title_fullStr |
Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipients |
title_full_unstemmed |
Soluble urokinase-type plasminogen activator receptor (suPAR) is a risk indicator for eGFR loss in kidney transplant recipients |
title_sort |
soluble urokinase-type plasminogen activator receptor (supar) is a risk indicator for egfr loss in kidney transplant recipients |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2021-02-01 |
description |
Abstract The prognostic significance of suPAR in various kidney diseases has recently been demonstrated. Its role in transplantation-specific outcomes is still largely unknown. Therefore, we prospectively investigated the prognostic relevance of suPAR in patients before and one year after kidney transplantation (KTx). We included 100 patients who had received a kidney transplantation between 2013 and 2015. The plasma concentration of suPAR was measured by ELISA assay. In recipients of living donations (LD), pre-transplant suPAR levels were significantly lower than those of recipients of deceased donations (DD). After KTx, suPAR levels significantly declined in LD and DD recipients, without a detectable difference between both groups any more. Higher suPAR levels in recipients one year after KTx were associated with a more severe eGFR loss in the following three years in multivariable cox-regression (n = 82, p = 0.021). suPAR-levels above 6212 pg/ml one year after KTx are associated with eGFR loss > 30%, which occurred almost twice as fast as in patients with suPAR ≤ 6212 pg/ml (p < 0.001). Hence, suPAR level at one year mark might be a risk indicator of increased eGFR loss. |
url |
https://doi.org/10.1038/s41598-021-83333-7 |
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