Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments
The mechanisms by which neoplastic cells disseminate from the primary tumor to metastatic sites, so-called metastatic organotropism, remain poorly understood. Epithelial–mesenchymal transition (EMT) plays a role in cancer development and progression by converting static epithelial cells into the mig...
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doaj-e633fa2d75574147b015e33657d99ee72020-12-01T00:02:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01219120912010.3390/ijms21239120Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional TreatmentsMaria Luisa Calabrò0Nayana Lazzari1Giulia Rigotto2Marco Tonello3Antonio Sommariva4Immunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, I-35128 Padua, ItalyImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, I-35128 Padua, ItalyImmunology and Molecular Oncology, Veneto Institute of Oncology IOV-IRCCS, I-35128 Padua, ItalySurgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, I-31033 Castelfranco Veneto (TV), ItalyAdvanced Surgical Oncology, Surgical Oncology of the Esophagus and Digestive Tract, Veneto Institute of Oncology IOV-IRCCS, I-31033 Castelfranco Veneto (TV), ItalyThe mechanisms by which neoplastic cells disseminate from the primary tumor to metastatic sites, so-called metastatic organotropism, remain poorly understood. Epithelial–mesenchymal transition (EMT) plays a role in cancer development and progression by converting static epithelial cells into the migratory and microenvironment-interacting mesenchymal cells, and by the modulation of chemoresistance and stemness of tumor cells. Several findings highlight that pathways involved in EMT and its reverse process (mesenchymal–epithelial transition, MET), now collectively called epithelial–mesenchymal plasticity (EMP), play a role in peritoneal metastases. So far, the relevance of factors linked to EMP in a unique peritoneal malignancy such as pseudomyxoma peritonei (PMP) has not been fully elucidated. In this review, we focus on the role of epithelial–mesenchymal dynamics in the metastatic process involving mucinous neoplastic dissemination in the peritoneum. In particular, we discuss the role of expression profiles and phenotypic transitions found in PMP in light of the recent concept of EMP. A better understanding of EMP-associated mechanisms driving peritoneal metastasis will help to provide a more targeted approach for PMP patients selected for locoregional interventions involving cytoreductive surgery and hyperthermic intraperitoneal chemotherapy.https://www.mdpi.com/1422-0067/21/23/9120pseudomyxoma peritoneiPMPepithelial-mesenchymal transitionepithelial-mesenchymal plasticityEMTEMP |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Maria Luisa Calabrò Nayana Lazzari Giulia Rigotto Marco Tonello Antonio Sommariva |
spellingShingle |
Maria Luisa Calabrò Nayana Lazzari Giulia Rigotto Marco Tonello Antonio Sommariva Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments International Journal of Molecular Sciences pseudomyxoma peritonei PMP epithelial-mesenchymal transition epithelial-mesenchymal plasticity EMT EMP |
author_facet |
Maria Luisa Calabrò Nayana Lazzari Giulia Rigotto Marco Tonello Antonio Sommariva |
author_sort |
Maria Luisa Calabrò |
title |
Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments |
title_short |
Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments |
title_full |
Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments |
title_fullStr |
Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments |
title_full_unstemmed |
Role of Epithelial–Mesenchymal Plasticity in Pseudomyxoma Peritonei: Implications for Locoregional Treatments |
title_sort |
role of epithelial–mesenchymal plasticity in pseudomyxoma peritonei: implications for locoregional treatments |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-11-01 |
description |
The mechanisms by which neoplastic cells disseminate from the primary tumor to metastatic sites, so-called metastatic organotropism, remain poorly understood. Epithelial–mesenchymal transition (EMT) plays a role in cancer development and progression by converting static epithelial cells into the migratory and microenvironment-interacting mesenchymal cells, and by the modulation of chemoresistance and stemness of tumor cells. Several findings highlight that pathways involved in EMT and its reverse process (mesenchymal–epithelial transition, MET), now collectively called epithelial–mesenchymal plasticity (EMP), play a role in peritoneal metastases. So far, the relevance of factors linked to EMP in a unique peritoneal malignancy such as pseudomyxoma peritonei (PMP) has not been fully elucidated. In this review, we focus on the role of epithelial–mesenchymal dynamics in the metastatic process involving mucinous neoplastic dissemination in the peritoneum. In particular, we discuss the role of expression profiles and phenotypic transitions found in PMP in light of the recent concept of EMP. A better understanding of EMP-associated mechanisms driving peritoneal metastasis will help to provide a more targeted approach for PMP patients selected for locoregional interventions involving cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. |
topic |
pseudomyxoma peritonei PMP epithelial-mesenchymal transition epithelial-mesenchymal plasticity EMT EMP |
url |
https://www.mdpi.com/1422-0067/21/23/9120 |
work_keys_str_mv |
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