Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis

Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis

Mycobacterium tuberculosis forms biofilms in vitro, but it is unclear whether biofilms are also formed during infection in vivo. Here, Chakraborty et al. demonstrate the formation of biofilms in animal models of infection and in patients with tuberculosis, and that biofilm formation can contribute t...

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Main Authors: Poushali Chakraborty, Sapna Bajeli, Deepak Kaushal, Bishan Dass Radotra, Ashwani Kumar
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21748-6
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spelling doaj-e6344464f0fb44cfa9b65724b192dc412021-03-11T11:34:14ZengNature Publishing GroupNature Communications2041-17232021-03-0112111710.1038/s41467-021-21748-6Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosisPoushali Chakraborty0Sapna Bajeli1Deepak Kaushal2Bishan Dass Radotra3Ashwani Kumar4Council of Scientific and Industrial Research, Institute of Microbial TechnologyCouncil of Scientific and Industrial Research, Institute of Microbial TechnologySouthwest National Primate Research Center, Texas Biomedical Research InstituteDepartment of Histopathology, Postgraduate Institute of Medical Education and ResearchCouncil of Scientific and Industrial Research, Institute of Microbial TechnologyMycobacterium tuberculosis forms biofilms in vitro, but it is unclear whether biofilms are also formed during infection in vivo. Here, Chakraborty et al. demonstrate the formation of biofilms in animal models of infection and in patients with tuberculosis, and that biofilm formation can contribute to drug tolerance.https://doi.org/10.1038/s41467-021-21748-6
collection DOAJ
language English
format Article
sources DOAJ
author Poushali Chakraborty
Sapna Bajeli
Deepak Kaushal
Bishan Dass Radotra
Ashwani Kumar
spellingShingle Poushali Chakraborty
Sapna Bajeli
Deepak Kaushal
Bishan Dass Radotra
Ashwani Kumar
Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
Nature Communications
author_facet Poushali Chakraborty
Sapna Bajeli
Deepak Kaushal
Bishan Dass Radotra
Ashwani Kumar
author_sort Poushali Chakraborty
title Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
title_short Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
title_full Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
title_fullStr Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
title_full_unstemmed Biofilm formation in the lung contributes to virulence and drug tolerance of Mycobacterium tuberculosis
title_sort biofilm formation in the lung contributes to virulence and drug tolerance of mycobacterium tuberculosis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-03-01
description Mycobacterium tuberculosis forms biofilms in vitro, but it is unclear whether biofilms are also formed during infection in vivo. Here, Chakraborty et al. demonstrate the formation of biofilms in animal models of infection and in patients with tuberculosis, and that biofilm formation can contribute to drug tolerance.
url https://doi.org/10.1038/s41467-021-21748-6
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AT sapnabajeli biofilmformationinthelungcontributestovirulenceanddrugtoleranceofmycobacteriumtuberculosis
AT deepakkaushal biofilmformationinthelungcontributestovirulenceanddrugtoleranceofmycobacteriumtuberculosis
AT bishandassradotra biofilmformationinthelungcontributestovirulenceanddrugtoleranceofmycobacteriumtuberculosis
AT ashwanikumar biofilmformationinthelungcontributestovirulenceanddrugtoleranceofmycobacteriumtuberculosis
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