KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

KCC2 Regulates Neuronal Excitability and Hippocampal Activity via Interaction with Task-3 Channels

Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders. Paradoxical, excitatory GABA signaling is usually assumed to contribute to abnormal network activity...

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Bibliographic Details
Main Authors: Marie Goutierre, Sana Al Awabdh, Florian Donneger, Emeline François, Daniel Gomez-Dominguez, Theano Irinopoulou, Liset Menendez de la Prida, Jean Christophe Poncer
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719307594

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