Prion protein post-translational modifications modulate heparan sulfate binding and limit aggregate size in prion disease
Many aggregation-prone proteins linked to neurodegenerative disease are post-translationally modified during their biogenesis. In vivo pathogenesis studies have suggested that the presence of post-translational modifications can shift the aggregate assembly pathway and profoundly alter the disease p...
Main Authors: | Julia A. Callender, Alejandro M. Sevillano, Katrin Soldau, Timothy D. Kurt, Taylor Schumann, Donald P. Pizzo, Hermann Altmeppen, Markus Glatzel, Jeffrey D. Esko, Christina J. Sigurdson |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2020-08-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996120302308 |
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