Anle138b partly ameliorates motor deficits despite failure of neuroprotection in a model of advanced multiple system atrophy
The neurodegenerative disorder multiple system atrophy (MSA) is characterized by autonomic failure, cerebellar ataxia and parkinsonism in any combination associated with predominantly oligodendroglial α-synuclein (α-syn) aggregates (glial cytoplasmic inclusions=GCIs). To date, there is no effective...
Main Authors: | Lisa eFellner, Daniela eKuzdas-Wood, Johannes eLevin, Sergey eRyazanov, Andrei eLeonov, Christian eGriesinger, Armin eGiese, Gregor K Wenning, Nadia eStefanova |
---|---|
Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2016-03-01
|
Series: | Frontiers in Neuroscience |
Subjects: | |
Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00099/full |
Similar Items
-
Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau
by: Matthias Brendel, et al.
Published: (2019-08-01) -
Oligomer modulator anle138b and related compounds in neurodegeneration and beyond
by: Ryazanov, Sergey
Published: (2020) -
Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial
by: Dalley, J.W, et al.
Published: (2022) -
Effects of anle138b treatment on amyloid-β neurotoxicity
by: Thomas, Carolina
Published: (2020) -
Untersuchung der Wirkung des antiaggregativen Compounds anle138b auf Löslichkeit und Toxizität von mutierter SOD1
by: Kleinknecht, Alexander
Published: (2017)