Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort
Abstract To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg...
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2020-03-01
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doaj-e6548854ca52425395b0c285c0c163752021-03-21T12:39:45ZengNature Publishing GroupScientific Reports2045-23222020-03-0110111210.1038/s41598-020-61706-8Prevalence and new onset of depression and anxiety among participants with AMD in a European cohortJasmin Rezapour0Alexander K. Schuster1Stefan Nickels2Christina A. Korb3Hisham Elbaz4Tunde Peto5Matthias Michal6Thomas Münzel7Philipp S. Wild8Jochem König9Karl Lackner10Andreas Schulz11Norbert Pfeiffer12Manfred E. Beutel13Department of Ophthalmology, University Medical Center of the Johannes Gutenberg-University MainzDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University MainzDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University MainzDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University MainzDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University MainzNIHR Biomedical Research Center at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of OphthalmologyDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University MainzCenter for Cardiology I, University Medical Center of the Johannes Gutenberg-University MainzPreventive Cardiology and Preventive Medicine/Center for Cardiology, University Medical Center of the Johannes Gutenberg-University MainzInstitute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University MainzInstitute for Clinical Chemistry and Laboratory Medicine, University Medical Center of the Johannes Gutenberg-University MainzCenter for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University MainzDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University MainzDepartment of Psychosomatic Medicine and Psychotherapy, University Medical Center of the Johannes Gutenberg-University MainzAbstract To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70–1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47–0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression.https://doi.org/10.1038/s41598-020-61706-8 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jasmin Rezapour Alexander K. Schuster Stefan Nickels Christina A. Korb Hisham Elbaz Tunde Peto Matthias Michal Thomas Münzel Philipp S. Wild Jochem König Karl Lackner Andreas Schulz Norbert Pfeiffer Manfred E. Beutel |
spellingShingle |
Jasmin Rezapour Alexander K. Schuster Stefan Nickels Christina A. Korb Hisham Elbaz Tunde Peto Matthias Michal Thomas Münzel Philipp S. Wild Jochem König Karl Lackner Andreas Schulz Norbert Pfeiffer Manfred E. Beutel Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort Scientific Reports |
author_facet |
Jasmin Rezapour Alexander K. Schuster Stefan Nickels Christina A. Korb Hisham Elbaz Tunde Peto Matthias Michal Thomas Münzel Philipp S. Wild Jochem König Karl Lackner Andreas Schulz Norbert Pfeiffer Manfred E. Beutel |
author_sort |
Jasmin Rezapour |
title |
Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort |
title_short |
Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort |
title_full |
Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort |
title_fullStr |
Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort |
title_full_unstemmed |
Prevalence and new onset of depression and anxiety among participants with AMD in a European cohort |
title_sort |
prevalence and new onset of depression and anxiety among participants with amd in a european cohort |
publisher |
Nature Publishing Group |
series |
Scientific Reports |
issn |
2045-2322 |
publishDate |
2020-03-01 |
description |
Abstract To investigate the prevalence and new onset of depression and anxiety among subjects with age-related macular degeneration (AMD) and its association with AMD in a large European cohort with relatively good visual acuity. 11,834 participants enrolled in the German population-based Gutenberg Health Study were studied. AMD was diagnosed by grading of fundus photographs. Depression and anxiety were assessed with the Patient Health Questionnaire and the Generalized Anxiety Disorder-2 Scale, respectively. Logistic regression analyses were performed and adjusted for several parameters. 1,089 (9.2%) participants were diagnosed having AMD. Prevalence of depression in AMD and non-AMD participants was 7.2% and 8.0%, respectively and prevalence of anxiety was 4.2% and 7.0%, respectively. New onset of depression and anxiety at 5-year follow-up in AMD subjects was 2.6% and 3.6%, respectively. AMD was not associated with depression (OR 0.93; CI 95% 0.70–1.20; p = 0.62). AMD was associated with less anxiety (OR 0.67; CI 95% 0.47–0.93; p = 0.02). This is the first study analyzing both prevalence and new onset of depression and anxiety in AMD subjects. AMD- and non-AMD participants had a similar prevalence and new onset of depression in our population-based sample. Participants without AMD had a higher prevalence of anxiety. AMD was not associated with depression. |
url |
https://doi.org/10.1038/s41598-020-61706-8 |
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