PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTS
Background. At present liver resection combined with chemotherapy is the only treatment for isolated resectable colorectal cancer liver metastases that potentially can achieve cure. Effective preoperative chemotherapy allows us to evaluate chemoresponsiveness of the tumor and increase metastases res...
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doaj-e65d51006b804e83b5c4d81a1936e9062021-07-29T08:12:53Zrus“ABV-press” Publishing house”, LLCТазовая хирургия и онкология2686-95942015-02-0103293410.17650/2220-3478-2014-0-3-29-3471PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTSE. V. Chernoglazova0G. V. Vyshinskaya1S. L. Gutorov2I. V. Sagaydak3A. N. Polyakov4Yа. V. Vishnevskaya5Yu. I. Patyutko6M. R. Lichinitser7Department of Combined Methods of Treatment N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowDepartment of Combined Methods of Treatment N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowDepartment of Combined Methods of Treatment N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowDepartment of Liver and Pancreatic Tumor Surgery N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowDepartment of Liver and Pancreatic Tumor Surgery N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowPathology Department FSBI N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoDepartment of Liver and Pancreatic Tumor Surgery N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowDepartment of Combined Methods of Treatment N.N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, MoscowBackground. At present liver resection combined with chemotherapy is the only treatment for isolated resectable colorectal cancer liver metastases that potentially can achieve cure. Effective preoperative chemotherapy allows us to evaluate chemoresponsiveness of the tumor and increase metastases resectability.Materials and methods. Between 2006 and 2011, 60 patients with potentially resectable colorectal cancer liver metastases were included in the study. All patients received preoperative oxaliplatin- or irinotecan-based chemotherapy; average duration of treatment was 3.6 ± 0.11 months. Liver resection was performed after chemotherapy: 29 (48.3 %) pts underwent hemihepatectomy, 11 (18.3 %) pts – extended hemihepatectomy and 20 (33.4 %) pts – segmentectomy. Pathologic response in liver metastases was assessed to analyze efficacy of preoperative chemotherapy.Results. Objective response to preoperative chemotherapy was observed in 33 (55 %) pts. 23 (38.3 %) patients had stable disease. The maximum effect of preoperative chemotherapy was achieved in patients with bilobar liver metastases, receiving combination with oxaliplatin – in 23 (63.9 %) cases. Side effects of 334 cycles of preoperative chemotherapy were assessed. In most cases, adverse events were not clinically significant. Side effects of grade III/IV in 18 (5.4 %) cycles were observed in 12 (20 %) patients. 52 (86.7 %) patients underwent R0-resections; 8 pts had R1 (n = 5) и R2 (n = 3) resections of metastases. There were no postoperative deaths. Pathologic response was observed in 55/60 (91.7 %) cases: grade I was seen in 17 (28.3 %) cases; grade II – in 14 (23.3 %); grade III – in 20 (33.3 %) and grade IV – in 4 (6.8 %) cases. Pathologic response of grade III/IV occurred in 63.6 % patients with partial treatment response and 13 % pts – with stable disease (р = 0.01).Conclusions. Highest efficacy of preoperative chemotherapy in combined treatment of colorectal cancer was achieved in patients with bilobar liver metastases. Safety of two-component chemotherapy regimens was confirmed. This study presents significant correlation between preoperative chemotherapy efficacy and pathologic response in liver metastases.https://ok.abvpress.ru/jour/article/view/77colorectal cancer liver metastasespreoperative chemotherapypathologic response |
collection |
DOAJ |
language |
Russian |
format |
Article |
sources |
DOAJ |
author |
E. V. Chernoglazova G. V. Vyshinskaya S. L. Gutorov I. V. Sagaydak A. N. Polyakov Yа. V. Vishnevskaya Yu. I. Patyutko M. R. Lichinitser |
spellingShingle |
E. V. Chernoglazova G. V. Vyshinskaya S. L. Gutorov I. V. Sagaydak A. N. Polyakov Yа. V. Vishnevskaya Yu. I. Patyutko M. R. Lichinitser PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTS Тазовая хирургия и онкология colorectal cancer liver metastases preoperative chemotherapy pathologic response |
author_facet |
E. V. Chernoglazova G. V. Vyshinskaya S. L. Gutorov I. V. Sagaydak A. N. Polyakov Yа. V. Vishnevskaya Yu. I. Patyutko M. R. Lichinitser |
author_sort |
E. V. Chernoglazova |
title |
PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTS |
title_short |
PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTS |
title_full |
PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTS |
title_fullStr |
PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTS |
title_full_unstemmed |
PREOPERATIVE CHEMOTHERAPY FOR COLORECTAL CANCER LIVER METASTASES: SHORT-TERM RESULTS |
title_sort |
preoperative chemotherapy for colorectal cancer liver metastases: short-term results |
publisher |
“ABV-press” Publishing house”, LLC |
series |
Тазовая хирургия и онкология |
issn |
2686-9594 |
publishDate |
2015-02-01 |
description |
Background. At present liver resection combined with chemotherapy is the only treatment for isolated resectable colorectal cancer liver metastases that potentially can achieve cure. Effective preoperative chemotherapy allows us to evaluate chemoresponsiveness of the tumor and increase metastases resectability.Materials and methods. Between 2006 and 2011, 60 patients with potentially resectable colorectal cancer liver metastases were included in the study. All patients received preoperative oxaliplatin- or irinotecan-based chemotherapy; average duration of treatment was 3.6 ± 0.11 months. Liver resection was performed after chemotherapy: 29 (48.3 %) pts underwent hemihepatectomy, 11 (18.3 %) pts – extended hemihepatectomy and 20 (33.4 %) pts – segmentectomy. Pathologic response in liver metastases was assessed to analyze efficacy of preoperative chemotherapy.Results. Objective response to preoperative chemotherapy was observed in 33 (55 %) pts. 23 (38.3 %) patients had stable disease. The maximum effect of preoperative chemotherapy was achieved in patients with bilobar liver metastases, receiving combination with oxaliplatin – in 23 (63.9 %) cases. Side effects of 334 cycles of preoperative chemotherapy were assessed. In most cases, adverse events were not clinically significant. Side effects of grade III/IV in 18 (5.4 %) cycles were observed in 12 (20 %) patients. 52 (86.7 %) patients underwent R0-resections; 8 pts had R1 (n = 5) и R2 (n = 3) resections of metastases. There were no postoperative deaths. Pathologic response was observed in 55/60 (91.7 %) cases: grade I was seen in 17 (28.3 %) cases; grade II – in 14 (23.3 %); grade III – in 20 (33.3 %) and grade IV – in 4 (6.8 %) cases. Pathologic response of grade III/IV occurred in 63.6 % patients with partial treatment response and 13 % pts – with stable disease (р = 0.01).Conclusions. Highest efficacy of preoperative chemotherapy in combined treatment of colorectal cancer was achieved in patients with bilobar liver metastases. Safety of two-component chemotherapy regimens was confirmed. This study presents significant correlation between preoperative chemotherapy efficacy and pathologic response in liver metastases. |
topic |
colorectal cancer liver metastases preoperative chemotherapy pathologic response |
url |
https://ok.abvpress.ru/jour/article/view/77 |
work_keys_str_mv |
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