Effect of carnitine supplementation on fatigue level in the gastrocnemius muscle of trained and sedentary rats
L-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplemen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universidade Federal de Santa Catarina
2012-04-01
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| Series: | Revista Brasileira de Cineantropometria e Desempenho Humano |
| Subjects: | |
| Online Access: | https://periodicos.ufsc.br/index.php/rbcdh/article/view/19207 |
| Summary: | L-carnitine, considered to be of great value in metabolic processes, plays an important role in the mitochondrial β-oxidation process. It may be used to improve athletic performance and to maintain a higher workload during exercise. This study aimed to investigate the effect of L-carnitine supplementation on muscle fatigue in sciatic nerve-gastrocnemius muscle preparations in sedentary and trained rats. The animals were divided into 4 groups: non-supplemented sedentary (NSS), supplemented sedentary (SS), non-supplemented trained (NST), and supplemented trained (ST) rats. The animals were trained in daily 1-h sessions (5 days/week) and received chronic oral L-carnitine supplementation (1 mg/mL) for 4 weeks. Muscle fatigue was determined by supramaximal tetanic stimulation of the sciatic nerve (50 Hz). Time values for strength reduction were significantly different (p<0.05) between NSS vs. SS and NST vs. ST rats. No significant differences were observed between SS vs. ST and NST vs. NSS rats. These findings demonstrate that L-carnitine lengthen the time required for induction of muscle fatigue. |
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| ISSN: | 1415-8426 1980-0037 |