Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activity
Background: Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Musculoskeletal ultrasound (MSUS) is an important tool for evaluation of patients with inflammatory arthritis as well as early detection of subclinical inflammation at the joint, tendon a...
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doaj-e6702a08753d4cdcbcbafcada24ed5ec2021-07-25T04:42:17ZengElsevierEgyptian Rheumatologist1110-11642021-10-01434305309Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activityDalia A. Elsherbiny0Reem A. Habeeb1Maryam A. Abdel Rahman2Heba A. Mustafa3Safaa A. Hussein4Internal Medicine Department, Division of Rheumatology, Ain Shams University, Cairo, EgyptInternal Medicine Department, Division of Rheumatology, Ain Shams University, Cairo, EgyptInternal Medicine Department, Division of Rheumatology, Ain Shams University, Cairo, EgyptInternal Medicine Department, Division of Rheumatology, Ain Shams University, Cairo, EgyptCorresponding author.; Internal Medicine Department, Division of Rheumatology, Ain Shams University, Cairo, EgyptBackground: Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Musculoskeletal ultrasound (MSUS) is an important tool for evaluation of patients with inflammatory arthritis as well as early detection of subclinical inflammation at the joint, tendon and entheseal level. Aim of the work: To investigate the frequency and distribution of lower limb entheseal abnormalities detected by MSUS in SLE patients and to evaluate its relation to disease activity. Patients and methods: 50 adult SLE patients were studied. SLE Disease Activity Index-2000 (SLEDAI-2K) was assessed. High-resolution MSUS assessment of quadriceps, patellar and Achilles tendons, and plantar fascia entheses was performed. Glasgow Ultrasound Enthesitis Scoring System (GUESS) was assessed. Results: The median age of the patients was 30 (interquartile range 23–36.3 years) and were 49 females. The median disease duration was 4 (2–8.3 years), SLEDAI-2K was 4 (2–8) and GUESS score 3 (1–5.3). Clinical enthesitis was found in 22 (44%) patients; 58% of the patients had evident MSUS features of enthesitis and 32% had minimal or isolated entheseal abnormalities. The age and SLEDAI-2K were significantly increased in those with clinical enthesitis compared to those without (p = 0.007 and p = 0.03 respectively). GUESS significantly correlated with the age (r = 0.39, p = 0.005) and SLEDAI-2K (r = 0.29, p = 0.04). Conclusion: Clinical and ultrasound-proved enthesitis are prevalent in SLE patients. Quadriceps tendon insertion is the most affected enthesis. Clinical enthesitis tends to occur in older SLE patients. Enthesitis has positive correlations with; age, and SLEDAI-2K score. The presence of enthesitis may represent a potential marker for SLE disease activity.http://www.sciencedirect.com/science/article/pii/S1110116420301289Musculoskeletal ultrasoundEnthesitisSLEDisease activityGUESS |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Dalia A. Elsherbiny Reem A. Habeeb Maryam A. Abdel Rahman Heba A. Mustafa Safaa A. Hussein |
spellingShingle |
Dalia A. Elsherbiny Reem A. Habeeb Maryam A. Abdel Rahman Heba A. Mustafa Safaa A. Hussein Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activity Egyptian Rheumatologist Musculoskeletal ultrasound Enthesitis SLE Disease activity GUESS |
author_facet |
Dalia A. Elsherbiny Reem A. Habeeb Maryam A. Abdel Rahman Heba A. Mustafa Safaa A. Hussein |
author_sort |
Dalia A. Elsherbiny |
title |
Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activity |
title_short |
Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activity |
title_full |
Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activity |
title_fullStr |
Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activity |
title_full_unstemmed |
Lower limb entheseal involvement in systemic lupus erythematosus patients: Relation to disease activity |
title_sort |
lower limb entheseal involvement in systemic lupus erythematosus patients: relation to disease activity |
publisher |
Elsevier |
series |
Egyptian Rheumatologist |
issn |
1110-1164 |
publishDate |
2021-10-01 |
description |
Background: Musculoskeletal involvement is extremely common in patients with systemic lupus erythematosus (SLE). Musculoskeletal ultrasound (MSUS) is an important tool for evaluation of patients with inflammatory arthritis as well as early detection of subclinical inflammation at the joint, tendon and entheseal level. Aim of the work: To investigate the frequency and distribution of lower limb entheseal abnormalities detected by MSUS in SLE patients and to evaluate its relation to disease activity. Patients and methods: 50 adult SLE patients were studied. SLE Disease Activity Index-2000 (SLEDAI-2K) was assessed. High-resolution MSUS assessment of quadriceps, patellar and Achilles tendons, and plantar fascia entheses was performed. Glasgow Ultrasound Enthesitis Scoring System (GUESS) was assessed. Results: The median age of the patients was 30 (interquartile range 23–36.3 years) and were 49 females. The median disease duration was 4 (2–8.3 years), SLEDAI-2K was 4 (2–8) and GUESS score 3 (1–5.3). Clinical enthesitis was found in 22 (44%) patients; 58% of the patients had evident MSUS features of enthesitis and 32% had minimal or isolated entheseal abnormalities. The age and SLEDAI-2K were significantly increased in those with clinical enthesitis compared to those without (p = 0.007 and p = 0.03 respectively). GUESS significantly correlated with the age (r = 0.39, p = 0.005) and SLEDAI-2K (r = 0.29, p = 0.04). Conclusion: Clinical and ultrasound-proved enthesitis are prevalent in SLE patients. Quadriceps tendon insertion is the most affected enthesis. Clinical enthesitis tends to occur in older SLE patients. Enthesitis has positive correlations with; age, and SLEDAI-2K score. The presence of enthesitis may represent a potential marker for SLE disease activity. |
topic |
Musculoskeletal ultrasound Enthesitis SLE Disease activity GUESS |
url |
http://www.sciencedirect.com/science/article/pii/S1110116420301289 |
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