Effect of Hydroalcoholic Extract of Ferollago angulata on Sperm and Testosterone Indices in Male Rats

• Main Authors: Somayeh Bohlouli, Gelavizh Rostami nasab
• Format: Article
• Language: fas
• Published: Ilam University of Medical Sciences 2019-09-01
• Series: Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām
• Subjects: Ferulago angulata; Fertility; Testosterone; Sperm; Male rat
• Online Access: http://sjimu.medilam.ac.ir/article-1-5350-en.html

Introduction: Sperm fertilization depends on different factors, such as sperm count, motility and morphology. Ferollago angulata has many antioxidant compounds. The purpose of this study was to determine the effect of hydroalcoholic extract Ferollago angulata on some semen indices and serum testosterone level in male rats.   Materials & Methods:This experimental study was carried out on 28 Wistar rats which were divided into 4 groups: one control, and three experimental groups treated with different doses of  Ferulago angulata extract (i.e.,100, 200 and 400mg/kg) .The extract injection was  administered intraperitoneally  for 21 days . Serum testosterone level, final body weight, testis weight and Sperm parameters including, morphology, Sperm count, high motility and viability were assayed at the end of study. The data were analyzed by one‐way ANOVA test and P<0.05 was considered statistically significant.   Findings: Our results showed  sperm parameters, including morphology, count, motility and viability of  male rats increased at 200 and 400 mg/kg of hydroalcoholic extract of Ferulago angulata (P<0.001). Testis weight and Serum testosterone level increased at 400 mg/kg of Ferulago angulata extract (P<0.001).   Discussion & Conclusions: Antioxidant compounds in Ferulago angulata improved the quality of sperm and fertility.