On Crowd-verification of Biological Networks
Biological networks with a structured syntax are a powerful way of representing biological information generated from high density data; however, they can become unwieldy to manage as their size and complexity increase. This article presents a crowd-verification approach for the visualization and ex...
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doaj-e6742986242b418087a5772ae6e374ff2020-11-25T03:43:55ZengSAGE PublishingBioinformatics and Biology Insights1177-93222013-01-01710.4137/BBI.S12932On Crowd-verification of Biological NetworksSam Ansari0Jean Binder1Stephanie Boue2Anselmo Di Fabio3William Hayes4Julia Hoeng5Anita Iskandar6Robin Kleiman7Raquel Norel8Bruce O'neel9Manuel C. Peitsch10Carine Poussin11Dexter Pratt12Kahn Rhrissorrakrai13Walter K. Schlage14Gustavo Stolovitzky15Marja Talikka16Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Applied Dynamic Solutions, LLC., NJ, USA.Selventa, Cambridge, MA, USA.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Selventa, Cambridge, MA, USA.IBM Computational Biology Center, Yorktown Heights, NY, USA.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.University of California San Diego, School of Medicine, Departments of Medicine and Bioengineering, La Jolla, CA, USA.IBM Computational Biology Center, Yorktown Heights, NY, USA.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.IBM Computational Biology Center, Yorktown Heights, NY, USA.Phillip Morris Products SA, Research and Development, Neuchâtel, Switzerland.Biological networks with a structured syntax are a powerful way of representing biological information generated from high density data; however, they can become unwieldy to manage as their size and complexity increase. This article presents a crowd-verification approach for the visualization and expansion of biological networks. Web-based graphical interfaces allow visualization of causal and correlative biological relationships represented using Biological Expression Language (BEL). Crowdsourcing principles enable participants to communally annotate these relationships based on literature evidences. Gamification principles are incorporated to further engage domain experts throughout biology to gather robust peer-reviewed information from which relationships can be identified and verified. The resulting network models will represent the current status of biological knowledge within the defined boundaries, here processes related to human lung disease. These models are amenable to computational analysis. For some period following conclusion of the challenge, the published models will remain available for continuous use and expansion by the scientific community.https://doi.org/10.4137/BBI.S12932 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Sam Ansari Jean Binder Stephanie Boue Anselmo Di Fabio William Hayes Julia Hoeng Anita Iskandar Robin Kleiman Raquel Norel Bruce O'neel Manuel C. Peitsch Carine Poussin Dexter Pratt Kahn Rhrissorrakrai Walter K. Schlage Gustavo Stolovitzky Marja Talikka |
spellingShingle |
Sam Ansari Jean Binder Stephanie Boue Anselmo Di Fabio William Hayes Julia Hoeng Anita Iskandar Robin Kleiman Raquel Norel Bruce O'neel Manuel C. Peitsch Carine Poussin Dexter Pratt Kahn Rhrissorrakrai Walter K. Schlage Gustavo Stolovitzky Marja Talikka On Crowd-verification of Biological Networks Bioinformatics and Biology Insights |
author_facet |
Sam Ansari Jean Binder Stephanie Boue Anselmo Di Fabio William Hayes Julia Hoeng Anita Iskandar Robin Kleiman Raquel Norel Bruce O'neel Manuel C. Peitsch Carine Poussin Dexter Pratt Kahn Rhrissorrakrai Walter K. Schlage Gustavo Stolovitzky Marja Talikka |
author_sort |
Sam Ansari |
title |
On Crowd-verification of Biological Networks |
title_short |
On Crowd-verification of Biological Networks |
title_full |
On Crowd-verification of Biological Networks |
title_fullStr |
On Crowd-verification of Biological Networks |
title_full_unstemmed |
On Crowd-verification of Biological Networks |
title_sort |
on crowd-verification of biological networks |
publisher |
SAGE Publishing |
series |
Bioinformatics and Biology Insights |
issn |
1177-9322 |
publishDate |
2013-01-01 |
description |
Biological networks with a structured syntax are a powerful way of representing biological information generated from high density data; however, they can become unwieldy to manage as their size and complexity increase. This article presents a crowd-verification approach for the visualization and expansion of biological networks. Web-based graphical interfaces allow visualization of causal and correlative biological relationships represented using Biological Expression Language (BEL). Crowdsourcing principles enable participants to communally annotate these relationships based on literature evidences. Gamification principles are incorporated to further engage domain experts throughout biology to gather robust peer-reviewed information from which relationships can be identified and verified. The resulting network models will represent the current status of biological knowledge within the defined boundaries, here processes related to human lung disease. These models are amenable to computational analysis. For some period following conclusion of the challenge, the published models will remain available for continuous use and expansion by the scientific community. |
url |
https://doi.org/10.4137/BBI.S12932 |
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