A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract
Several biological activities of pomegranate have been widely described in the literature, but the anti-inflammatory effect in the gastrointestinal tract has not been reviewed till now. The aim of the present paper is to summarize the evidence for or against the efficacy of pomegranate for coping wi...
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Online Access: | http://dx.doi.org/10.1155/2013/247145 |
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doaj-e674ba1ab7484d168da2a4672d5bb1042020-11-24T21:59:08ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882013-01-01201310.1155/2013/247145247145A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal TractElisa Colombo0Enrico Sangiovanni1Mario Dell'Agli2Department of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, Milano, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, Milano, ItalyDepartment of Pharmacological and Biomolecular Sciences, Università degli Studi di Milano, Via Balzaretti 9, Milano, ItalySeveral biological activities of pomegranate have been widely described in the literature, but the anti-inflammatory effect in the gastrointestinal tract has not been reviewed till now. The aim of the present paper is to summarize the evidence for or against the efficacy of pomegranate for coping with inflammatory conditions of the gastro-intestinal tract. The paper has been organized in three parts: (1) the first one is devoted to the modifications of pomegranate active compounds in the gastro-intestinal tract; (2) the second one considering the literature regarding the anti-inflammatory effect of pomegranate at gastric level; (3) the third part considers the anti-inflammatory effect of pomegranate in the gut. In vivo studies performed on the whole fruit or juice, peel, and flowers demonstrate antiulcer effect in a variety of animal models. Ellagic acid was the main responsible for this effect, although other individual ellagitannins could contribute to the biological activity of the mixture. Different preparations of pomegranate, including extracts from peels, flowers, seeds, and juice, show a significant anti-inflammatory activity in the gut. No clinical studies have been found, thus suggesting that future clinical studies are necessary to clarify the beneficial effects of pomegranate in the gastrointestinal tract.http://dx.doi.org/10.1155/2013/247145 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Elisa Colombo Enrico Sangiovanni Mario Dell'Agli |
spellingShingle |
Elisa Colombo Enrico Sangiovanni Mario Dell'Agli A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract Evidence-Based Complementary and Alternative Medicine |
author_facet |
Elisa Colombo Enrico Sangiovanni Mario Dell'Agli |
author_sort |
Elisa Colombo |
title |
A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract |
title_short |
A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract |
title_full |
A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract |
title_fullStr |
A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract |
title_full_unstemmed |
A Review on the Anti-Inflammatory Activity of Pomegranate in the Gastrointestinal Tract |
title_sort |
review on the anti-inflammatory activity of pomegranate in the gastrointestinal tract |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2013-01-01 |
description |
Several biological activities of pomegranate have been widely described in the literature, but the anti-inflammatory effect in the gastrointestinal tract has not been reviewed till now. The aim of the present paper is to summarize the evidence for or against the efficacy of pomegranate for coping with inflammatory conditions of the gastro-intestinal tract. The paper has been organized in three parts: (1) the first one is devoted to the modifications of pomegranate active compounds in the gastro-intestinal tract; (2) the second one considering the literature regarding the anti-inflammatory effect of pomegranate at gastric level; (3) the third part considers the anti-inflammatory effect of pomegranate in the gut. In vivo studies performed on the whole fruit or juice, peel, and flowers demonstrate antiulcer effect in a variety of animal models. Ellagic acid was the main responsible for this effect, although other individual ellagitannins could contribute to the biological activity of the mixture. Different preparations of pomegranate, including extracts from peels, flowers, seeds, and juice, show a significant anti-inflammatory activity in the gut. No clinical studies have been found, thus suggesting that future clinical studies are necessary to clarify the beneficial effects of pomegranate in the gastrointestinal tract. |
url |
http://dx.doi.org/10.1155/2013/247145 |
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