Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears
Although rotator cuff (RC) tendinopathy is a frequent pathology of the shoulder, the real understanding of its aetiopathogenesis is still unclear. Several studies showed that RC tendinopathy is more frequent in patients with hyperglycemia, diabetes, obesity, or metabolic syndrome. This paper aims to...
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Series: | International Journal of Endocrinology |
Online Access: | http://dx.doi.org/10.1155/2014/685820 |
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doaj-e67769f5d4764fadba639e41f024a0972020-11-24T22:35:07ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452014-01-01201410.1155/2014/685820685820Role of Serum Fibrinogen Levels in Patients with Rotator Cuff TearsUmile Giuseppe Longo0Stefano Petrillo1Alessandra Berton2Filippo Spiezia3Mattia Loppini4Nicola Maffulli5Vincenzo Denaro6Department of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyCentre for Sports and Exercise Medicine, Mile End Hospital, Mann Ward, 275 Bancroft Road, London E1 4DG, UKDepartment of Orthopaedic and Trauma Surgery, Campus Bio-Medico University, Via Alvaro del Portillo 200, Trigoria, 00128 Rome, ItalyAlthough rotator cuff (RC) tendinopathy is a frequent pathology of the shoulder, the real understanding of its aetiopathogenesis is still unclear. Several studies showed that RC tendinopathy is more frequent in patients with hyperglycemia, diabetes, obesity, or metabolic syndrome. This paper aims to evaluate the serum concentration of fibrinogen in patients with RC tears. Metabolic disorders have been related to high concentration of serum fibrinogen and the activity of fibrinogen has been proven to be crucial in the development of microvascular damage. Thus, it may produce progression of RC degeneration by reducing the vascular supply of tendons. We report the results of a cross-sectional frequency-matched case-control study comparing the serum concentration of fibrinogen of patients with RC tears with that of a control group of patients without history of RC tears who underwent arthroscopic meniscectomy. We choose to enrol in the control group patients with pathology of the lower limb with a likely mechanic, not metabolic, cause, different from tendon pathology. We found no statistically significant differences in serum concentration of fibrinogen when comparing patients with RC tears and patients who underwent arthroscopic meniscectomy (P = 0.5). Further studies are necessary to clarify the role of fibrinogen in RC disease.http://dx.doi.org/10.1155/2014/685820 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Umile Giuseppe Longo Stefano Petrillo Alessandra Berton Filippo Spiezia Mattia Loppini Nicola Maffulli Vincenzo Denaro |
spellingShingle |
Umile Giuseppe Longo Stefano Petrillo Alessandra Berton Filippo Spiezia Mattia Loppini Nicola Maffulli Vincenzo Denaro Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears International Journal of Endocrinology |
author_facet |
Umile Giuseppe Longo Stefano Petrillo Alessandra Berton Filippo Spiezia Mattia Loppini Nicola Maffulli Vincenzo Denaro |
author_sort |
Umile Giuseppe Longo |
title |
Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears |
title_short |
Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears |
title_full |
Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears |
title_fullStr |
Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears |
title_full_unstemmed |
Role of Serum Fibrinogen Levels in Patients with Rotator Cuff Tears |
title_sort |
role of serum fibrinogen levels in patients with rotator cuff tears |
publisher |
Hindawi Limited |
series |
International Journal of Endocrinology |
issn |
1687-8337 1687-8345 |
publishDate |
2014-01-01 |
description |
Although rotator cuff (RC) tendinopathy is a frequent pathology of the shoulder, the real understanding of its aetiopathogenesis is still unclear. Several studies showed that RC tendinopathy is more frequent in patients with hyperglycemia, diabetes, obesity, or metabolic syndrome. This paper aims to evaluate the serum concentration of fibrinogen in patients with RC tears. Metabolic disorders have been related to high concentration of serum fibrinogen and the activity of fibrinogen has been proven to be crucial in the development of microvascular damage. Thus, it may produce progression of RC degeneration by reducing the vascular supply of tendons. We report the results of a cross-sectional frequency-matched case-control study comparing the serum concentration of fibrinogen of patients with RC tears with that of a control group of patients without history of RC tears who underwent arthroscopic meniscectomy. We choose to enrol in the control group patients with pathology of the lower limb with a likely mechanic, not metabolic, cause, different from tendon pathology. We found no statistically significant differences in serum concentration of fibrinogen when comparing patients with RC tears and patients who underwent arthroscopic meniscectomy (P = 0.5). Further studies are necessary to clarify the role of fibrinogen in RC disease. |
url |
http://dx.doi.org/10.1155/2014/685820 |
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