Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair

Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair

Since material stiffness controls many cell functions, we reviewed the currently available knowledge on stiffness sensing and elucidated what is known in the context of clinical and experimental articular cartilage (AC) repair. Remarkably, no stiffness information on the various biomaterials for cli...

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Bibliographic Details
Main Authors: Mischa Selig, Jasmin C. Lauer, Melanie L. Hart, Bernd Rolauffs
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
mechanotransduction
stiffness sensing
mesenchymal stromal cells (MSCs)
chondrocyte
articular cartilage
osteoarthritis
Online Access:https://www.mdpi.com/1422-0067/21/15/5399

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