Multi potent aromatic nano colloid: synthesis, characterization and applications
Abstract In this study the aromatic nanocolloids (CANCs) are synthesized using the noble metal silver by using Citronella extract and confirmed through physio chemical analysis. The synthesised CANCs were evaluated for its antimicrobial activity and antibiofilm activity against pathogenic biofilm fo...
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doaj-e699377a94d6496bad4639f31d69e8602020-11-25T02:36:31ZengSpringerOpenAMB Express2191-08552020-09-0110111210.1186/s13568-020-01104-5Multi potent aromatic nano colloid: synthesis, characterization and applicationsRanjani Soundhararajan0Salman Al Farzi Mohamed Sheik Meeran1Shruthy Priya Prakash2Waseem Mohammad3Ruckmani Kandasamy4Hemalatha Srinivasan5School of Life Sciences, B. S. Abdur Rahman Crescent institute of Science and TechnologySchool of Life Sciences, B. S. Abdur Rahman Crescent institute of Science and TechnologySchool of Life Sciences, B. S. Abdur Rahman Crescent institute of Science and TechnologySchool of Life Sciences, B. S. Abdur Rahman Crescent institute of Science and TechnologyDepartment of Pharmaceutical Technology, University College of EngineeringSchool of Life Sciences, B. S. Abdur Rahman Crescent institute of Science and TechnologyAbstract In this study the aromatic nanocolloids (CANCs) are synthesized using the noble metal silver by using Citronella extract and confirmed through physio chemical analysis. The synthesised CANCs were evaluated for its antimicrobial activity and antibiofilm activity against pathogenic biofilm forming E. coli. In addition, synthesized CANCs were evaluated for the expression of virulent genes encoding AmpC and CTX-M-15. The results confirmed that CANCs showed effective antimicrobial activity through its bacteriostatic, bactericidal and quorum quencher activity and downregulated CTX-M-15 gene. CANCs were validated as alternate to the commercial fungicides to control plant pathogenic fungi such as A. niger MTCC (281), Fusarium graminearum MTCC (2089) and F. udum MTCC (2204). Furthermore, analysis of CANCs on breast cancer (MCF-7) cells under in vitro condition showed that the cytotoxicity of CANCs is dose dependent. Thus, the multifunctional CANCs can be utilized as potential antimicrobial, antifungal and anticancer agent.http://link.springer.com/article/10.1186/s13568-020-01104-5Aromatic nanocolloidsCTX-M-15AmpCAntibiotic resistanceFungicideBreast cancer MCF-7 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ranjani Soundhararajan Salman Al Farzi Mohamed Sheik Meeran Shruthy Priya Prakash Waseem Mohammad Ruckmani Kandasamy Hemalatha Srinivasan |
spellingShingle |
Ranjani Soundhararajan Salman Al Farzi Mohamed Sheik Meeran Shruthy Priya Prakash Waseem Mohammad Ruckmani Kandasamy Hemalatha Srinivasan Multi potent aromatic nano colloid: synthesis, characterization and applications AMB Express Aromatic nanocolloids CTX-M-15 AmpC Antibiotic resistance Fungicide Breast cancer MCF-7 |
author_facet |
Ranjani Soundhararajan Salman Al Farzi Mohamed Sheik Meeran Shruthy Priya Prakash Waseem Mohammad Ruckmani Kandasamy Hemalatha Srinivasan |
author_sort |
Ranjani Soundhararajan |
title |
Multi potent aromatic nano colloid: synthesis, characterization and applications |
title_short |
Multi potent aromatic nano colloid: synthesis, characterization and applications |
title_full |
Multi potent aromatic nano colloid: synthesis, characterization and applications |
title_fullStr |
Multi potent aromatic nano colloid: synthesis, characterization and applications |
title_full_unstemmed |
Multi potent aromatic nano colloid: synthesis, characterization and applications |
title_sort |
multi potent aromatic nano colloid: synthesis, characterization and applications |
publisher |
SpringerOpen |
series |
AMB Express |
issn |
2191-0855 |
publishDate |
2020-09-01 |
description |
Abstract In this study the aromatic nanocolloids (CANCs) are synthesized using the noble metal silver by using Citronella extract and confirmed through physio chemical analysis. The synthesised CANCs were evaluated for its antimicrobial activity and antibiofilm activity against pathogenic biofilm forming E. coli. In addition, synthesized CANCs were evaluated for the expression of virulent genes encoding AmpC and CTX-M-15. The results confirmed that CANCs showed effective antimicrobial activity through its bacteriostatic, bactericidal and quorum quencher activity and downregulated CTX-M-15 gene. CANCs were validated as alternate to the commercial fungicides to control plant pathogenic fungi such as A. niger MTCC (281), Fusarium graminearum MTCC (2089) and F. udum MTCC (2204). Furthermore, analysis of CANCs on breast cancer (MCF-7) cells under in vitro condition showed that the cytotoxicity of CANCs is dose dependent. Thus, the multifunctional CANCs can be utilized as potential antimicrobial, antifungal and anticancer agent. |
topic |
Aromatic nanocolloids CTX-M-15 AmpC Antibiotic resistance Fungicide Breast cancer MCF-7 |
url |
http://link.springer.com/article/10.1186/s13568-020-01104-5 |
work_keys_str_mv |
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