Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2
Nitrogen permease regulator-like 2 (NPRL2) is a component of a conserved complex that inhibits mTORC1 (mammalian Target Of Rapamycin Complex 1) in response to amino acid insufficiency. Here, we show that NPRL2 is required for mouse viability and that its absence significantly compromises fetal liver...
Main Authors: | Paul A. Dutchak, Sunil Laxman, Sandi Jo Estill, Chensu Wang, Yun Wang, Yiguang Wang, Gamze B. Bulut, Jinming Gao, Lily J. Huang, Benjamin P. Tu |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2015-07-01
|
Series: | Cell Reports |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124715006543 |
Similar Items
-
FKBP39 controls nutrient dependent Nprl3 expression and TORC1 activity in Drosophila
by: Ying Zhou, et al.
Published: (2021-06-01) -
The role of NPRL2 and NPRL3 in neural development and disorders
by: Ssu-Yu Yeh, et al.
Published: (2019) -
Regulation of colonic epithelial cell homeostasis by mTORC1
by: Takenori Kotani, et al.
Published: (2020-08-01) -
mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome
by: Yoana Rabanal-Ruiz, et al.
Published: (2018-03-01) -
Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
by: Haiyang Tang, PhD, et al.
Published: (2018-12-01)