Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases

Oxidative stress (OS) damage can cause significant injury to cells, which is related to the occurrence and development of many diseases. This pathological process is considered to be the first step to trigger the death of outer retinal neurons, which is related to the pathology of retinal degenerati...

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Main Authors:	Panpan Li, Hanhan Liu, Xin Shi, Verena Prokosch
Format:	Article
Language:	English
Published:	MDPI AG 2021-04-01
Series:	Molecules
Subjects:	oxidative stress hydrogen sulfide retinal degeneration diseases endogenous exogenous
Online Access:	https://www.mdpi.com/1420-3049/26/9/2411

id	doaj-e6a91b11f0854842830ebe2d178029ee
record_format	Article
spelling	doaj-e6a91b11f0854842830ebe2d178029ee2021-04-21T23:02:55ZengMDPI AGMolecules1420-30492021-04-01262411241110.3390/molecules26092411Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration DiseasesPanpan Li0Hanhan Liu1Xin Shi2Verena Prokosch3Department of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyDepartment of Ophthalmology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50937 Cologne, GermanyOxidative stress (OS) damage can cause significant injury to cells, which is related to the occurrence and development of many diseases. This pathological process is considered to be the first step to trigger the death of outer retinal neurons, which is related to the pathology of retinal degenerative diseases. Hydrogen sulfide (H<sub>2</sub>S) has recently received widespread attention as a physiological signal molecule and gas neuromodulator and plays an important role in regulating OS in eyes. In this article, we reviewed the OS responses and regulatory mechanisms of H<sub>2</sub>S and its donors as endogenous and exogenous regulators in retinal degenerative diseases. Understanding the relevant mechanisms will help to identify the therapeutic potential of H<sub>2</sub>S in retinal degenerative diseases.https://www.mdpi.com/1420-3049/26/9/2411oxidative stresshydrogen sulfideretinal degeneration diseasesendogenousexogenous
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Panpan Li Hanhan Liu Xin Shi Verena Prokosch
spellingShingle	Panpan Li Hanhan Liu Xin Shi Verena Prokosch Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases Molecules oxidative stress hydrogen sulfide retinal degeneration diseases endogenous exogenous
author_facet	Panpan Li Hanhan Liu Xin Shi Verena Prokosch
author_sort	Panpan Li
title	Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases
title_short	Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases
title_full	Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases
title_fullStr	Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases
title_full_unstemmed	Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases
title_sort	hydrogen sulfide: novel endogenous and exogenous modulator of oxidative stress in retinal degeneration diseases
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-04-01
description	Oxidative stress (OS) damage can cause significant injury to cells, which is related to the occurrence and development of many diseases. This pathological process is considered to be the first step to trigger the death of outer retinal neurons, which is related to the pathology of retinal degenerative diseases. Hydrogen sulfide (H<sub>2</sub>S) has recently received widespread attention as a physiological signal molecule and gas neuromodulator and plays an important role in regulating OS in eyes. In this article, we reviewed the OS responses and regulatory mechanisms of H<sub>2</sub>S and its donors as endogenous and exogenous regulators in retinal degenerative diseases. Understanding the relevant mechanisms will help to identify the therapeutic potential of H<sub>2</sub>S in retinal degenerative diseases.
topic	oxidative stress hydrogen sulfide retinal degeneration diseases endogenous exogenous
url	https://www.mdpi.com/1420-3049/26/9/2411
work_keys_str_mv	AT panpanli hydrogensulfidenovelendogenousandexogenousmodulatorofoxidativestressinretinaldegenerationdiseases AT hanhanliu hydrogensulfidenovelendogenousandexogenousmodulatorofoxidativestressinretinaldegenerationdiseases AT xinshi hydrogensulfidenovelendogenousandexogenousmodulatorofoxidativestressinretinaldegenerationdiseases AT verenaprokosch hydrogensulfidenovelendogenousandexogenousmodulatorofoxidativestressinretinaldegenerationdiseases
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Hydrogen Sulfide: Novel Endogenous and Exogenous Modulator of Oxidative Stress in Retinal Degeneration Diseases

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