Autophagy inhibition enhances PD-L1 expression in gastric cancer

Autophagy inhibition enhances PD-L1 expression in gastric cancer

Abstract Background Autophagy, a process for degrading intracellular substances to maintain basal metabolic turnover, is known to be perturbed in gastric cancer. Programmed cell death-1 (PD-1) with its ligand (PD-L1) are important immune checkpoint proteins and their regulation by autophagy has been...

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Bibliographic Details
Main Authors: Xiaojuan Wang, William K. K. Wu, Jing Gao, Zhongwu Li, Bin Dong, Xiaoting Lin, Yilin Li, Yanyan Li, Jifang Gong, Changsong Qi, Zhi Peng, Jun Yu, Lin Shen
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Autophagy
PD-L1
Gastric cancer
NF-κB
Online Access:http://link.springer.com/article/10.1186/s13046-019-1148-5

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