Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction
Abstract Background Low birthweight, intrauterine growth restriction (IUGR) and perinatal mortality have been associated with air pollution. However, intervention studies that use ultrasound measurements to assess the effects of household air pollution (HAP) on fetal biometric parameters (FBP) are r...
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doaj-e6ac99a8f9224ec0ac830ad4943bf4bf2021-07-04T11:43:51ZengBMCEnvironmental Health1476-069X2021-06-012011910.1186/s12940-021-00756-5Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restrictionAnindita Dutta0Donee Alexander1Theodore Karrison2Oludare Morhasson-Bello3Nathaniel Wilson4Omolola Mojisola Atalabi5Damilola Adu6Tope Ibigbami7Samuel Adekunle8Dayo Adepoju9John Olamijulo10Omolola Akinwunmi11Oluniyi S. Afolabi12Oluwafunmilade Deji-Abiodun13Babatunde Adedokun14Briseis Aschebrook-Kilfoy15Oladosu Ojengbede16Christopher O. Olopade17Department of Medicine and Center for Global Health, University of ChicagoDepartment of Medicine and Center for Global Health, University of ChicagoDepartment of Public Health Sciences, University of ChicagoDepartment of Obstetrics and Gynecology, University of IbadanPritzker School of Medicine, University of ChicagoDepartment of Radiology, University of IbadanHealthy Life for All Foundation, House 38, University College HospitalHealthy Life for All Foundation, House 38, University College HospitalHealthy Life for All Foundation, House 38, University College HospitalHealthy Life for All Foundation, House 38, University College HospitalHealthy Life for All Foundation, House 38, University College HospitalDepartment of Radiology, University of IbadanDepartment of Radiology, University of IbadanDepartment of Medicine and Center for Global Health, University of ChicagoDepartment of Medicine and Center for Global Health, University of ChicagoDepartment of Public Health Sciences, University of ChicagoDepartment of Obstetrics and Gynecology, University of IbadanDepartment of Medicine and Center for Global Health, University of ChicagoAbstract Background Low birthweight, intrauterine growth restriction (IUGR) and perinatal mortality have been associated with air pollution. However, intervention studies that use ultrasound measurements to assess the effects of household air pollution (HAP) on fetal biometric parameters (FBP) are rare. We investigated the effect of a cookstove intervention on FBP and IUGR in a randomized controlled trial (RCT) cohort of HAP-exposed pregnant Nigerian women. Methods We recruited 324 women early in the second trimester of pregnancy. Between 16 and 18 weeks, we randomized them to either continue cooking with firewood/kerosene (control group) or receive a CleanCook stove and ethanol fuel (intervention group). We measured fetal biparietal diameter (BPD), head circumference (HC), femur length (FL), abdominal circumference (AC) and ultrasound-estimated fetal weight (U-EFW) in the second and third trimesters. The women were clinically followed up at six regular time points during their pregnancies. Once during the women’s second trimester and once during the third, we made 72-h continuous measurements of their personal exposures to particulate matter having aerodynamic diameter < 2.5 μm (PM2.5). We adopted a modified intent-to-treat approach for the analysis. Differences between the intervention and control groups on impact of HAP on fetal growth trajectories were analyzed using mixed effects regression models. Results There were no significant differences in fetal growth trajectories between the intervention and control groups. Conclusions Larger studies in a setting of low ambient air pollution are required to further investigate the effect of transitioning to a cleaner fuel such as ethanol on intrauterine growth. Trial registration ClinicalTrials.gov NCT02394574 ; September 2012https://doi.org/10.1186/s12940-021-00756-5Household air pollutionFetal growthUltrasound measurementIntrauterine growth restrictionPregnant womenNigeria |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Anindita Dutta Donee Alexander Theodore Karrison Oludare Morhasson-Bello Nathaniel Wilson Omolola Mojisola Atalabi Damilola Adu Tope Ibigbami Samuel Adekunle Dayo Adepoju John Olamijulo Omolola Akinwunmi Oluniyi S. Afolabi Oluwafunmilade Deji-Abiodun Babatunde Adedokun Briseis Aschebrook-Kilfoy Oladosu Ojengbede Christopher O. Olopade |
spellingShingle |
Anindita Dutta Donee Alexander Theodore Karrison Oludare Morhasson-Bello Nathaniel Wilson Omolola Mojisola Atalabi Damilola Adu Tope Ibigbami Samuel Adekunle Dayo Adepoju John Olamijulo Omolola Akinwunmi Oluniyi S. Afolabi Oluwafunmilade Deji-Abiodun Babatunde Adedokun Briseis Aschebrook-Kilfoy Oladosu Ojengbede Christopher O. Olopade Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction Environmental Health Household air pollution Fetal growth Ultrasound measurement Intrauterine growth restriction Pregnant women Nigeria |
author_facet |
Anindita Dutta Donee Alexander Theodore Karrison Oludare Morhasson-Bello Nathaniel Wilson Omolola Mojisola Atalabi Damilola Adu Tope Ibigbami Samuel Adekunle Dayo Adepoju John Olamijulo Omolola Akinwunmi Oluniyi S. Afolabi Oluwafunmilade Deji-Abiodun Babatunde Adedokun Briseis Aschebrook-Kilfoy Oladosu Ojengbede Christopher O. Olopade |
author_sort |
Anindita Dutta |
title |
Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction |
title_short |
Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction |
title_full |
Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction |
title_fullStr |
Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction |
title_full_unstemmed |
Household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction |
title_sort |
household air pollution, ultrasound measurement, fetal biometric parameters and intrauterine growth restriction |
publisher |
BMC |
series |
Environmental Health |
issn |
1476-069X |
publishDate |
2021-06-01 |
description |
Abstract Background Low birthweight, intrauterine growth restriction (IUGR) and perinatal mortality have been associated with air pollution. However, intervention studies that use ultrasound measurements to assess the effects of household air pollution (HAP) on fetal biometric parameters (FBP) are rare. We investigated the effect of a cookstove intervention on FBP and IUGR in a randomized controlled trial (RCT) cohort of HAP-exposed pregnant Nigerian women. Methods We recruited 324 women early in the second trimester of pregnancy. Between 16 and 18 weeks, we randomized them to either continue cooking with firewood/kerosene (control group) or receive a CleanCook stove and ethanol fuel (intervention group). We measured fetal biparietal diameter (BPD), head circumference (HC), femur length (FL), abdominal circumference (AC) and ultrasound-estimated fetal weight (U-EFW) in the second and third trimesters. The women were clinically followed up at six regular time points during their pregnancies. Once during the women’s second trimester and once during the third, we made 72-h continuous measurements of their personal exposures to particulate matter having aerodynamic diameter < 2.5 μm (PM2.5). We adopted a modified intent-to-treat approach for the analysis. Differences between the intervention and control groups on impact of HAP on fetal growth trajectories were analyzed using mixed effects regression models. Results There were no significant differences in fetal growth trajectories between the intervention and control groups. Conclusions Larger studies in a setting of low ambient air pollution are required to further investigate the effect of transitioning to a cleaner fuel such as ethanol on intrauterine growth. Trial registration ClinicalTrials.gov NCT02394574 ; September 2012 |
topic |
Household air pollution Fetal growth Ultrasound measurement Intrauterine growth restriction Pregnant women Nigeria |
url |
https://doi.org/10.1186/s12940-021-00756-5 |
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