STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.

STN1 OB Fold Mutation Alters DNA Binding and Affects Selective Aspects of CST Function.

Mammalian CST (CTC1-STN1-TEN1) participates in multiple aspects of telomere replication and genome-wide recovery from replication stress. CST resembles Replication Protein A (RPA) in that it binds ssDNA and STN1 and TEN1 are structurally similar to RPA2 and RPA3. Conservation between CTC1 and RPA1 i...

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Bibliographic Details
Main Authors: Anukana Bhattacharjee, Jason Stewart, Mary Chaiken, Carolyn M Price
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5045167?pdf=render

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