| Summary: | Summary: Working memory is mediated by the coordinated activation of frontal and parietal cortices occurring in the theta and alpha frequency ranges. Here, we test whether electrically stimulating frontal and parietal regions at the frequency of interaction is effective in modulating working memory. We identify working memory nodes that are functionally connected in theta and alpha frequency bands and intracranially stimulate both nodes simultaneously in participants performing working memory tasks. We find that in-phase stimulation results in improvements in performance compared to sham stimulation. In addition, in-phase stimulation results in decreased phase lag between regions within working memory network, while anti-phase stimulation results in increased phase lag, suggesting that shorter phase lag in oscillatory connectivity may lead to better performance. The results support the idea that phase lag may play a key role in information transmission across brain regions. Thus, brain stimulation strategies to improve cognition may require targeting multiple nodes of brain networks. : Alagapan et al. use intracranial stimulation to simultaneously target multiple nodes of the working memory network. Functional connectivity within the network increases with stimulation, while task performance and phase lag between nodes in the network depend on the relative timing between stimulation. Keywords: cortical oscillations, intracranial eeg, human neuroscience, direct cortical stimulation, brain stimulation, working memory, phase lag
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