Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis
Abstract Background Estimating prevalence of Chlamydia trachomatis (CT) worldwide is necessary in designing control programs and allocating health resources. We performed a meta-analysis to calculate the prevalence of CT in the general population. Methods The Pubmed and Embase databases were searche...
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doaj-e6c28c60bd994f9d8facb368482810592020-11-25T03:47:13ZengBMCBMC Infectious Diseases1471-23342020-08-012011810.1186/s12879-020-05307-wPrevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysisPengcheng Huai0Furong Li1Tongsheng Chu2Dianchang Liu3Jian Liu4Furen Zhang5Shandong Provincial Hospital for Skin Disease, Shandong First Medical UniversityShandong Provincial Hospital for Skin Disease, Shandong First Medical UniversityShandong Provincial Hospital for Skin Disease, Shandong First Medical UniversityShandong Provincial Hospital for Skin Disease, Shandong First Medical UniversityShandong Provincial Hospital for Skin Disease, Shandong First Medical UniversityShandong Provincial Hospital for Skin Disease, Shandong First Medical UniversityAbstract Background Estimating prevalence of Chlamydia trachomatis (CT) worldwide is necessary in designing control programs and allocating health resources. We performed a meta-analysis to calculate the prevalence of CT in the general population. Methods The Pubmed and Embase databases were searched for eligible population-based studies from its inception through June 5, 2019. Q test and I 2 statistic were used to calculate the heterogeneity between studies. Random effects models were used to pool the prevalence of CT. Meta regression was performed to explore the possible sources of heterogeneity. Publication bias was evaluated using a funnel plot and “trim and fill” method. Results Twenty nine studies that reported prevalence of CT infection from 24 countries were identified, including a total population of 89,886 persons. The pooled prevalence of CT among the general population was 2.9% (95% CI, 2.4–3.5%), and females had a higher CT prevalence (3.1, 95% CI, 2.5–3.8%) than males (2.6, 95% CI, 2.0–3.2%) (χ 2 = 10.38, P < 0.01). Prevalence of CT was highest in region of America (4.5, 95% CI, 3.1–5.9%), especially in Latin America (6.7, 95% CI, 5.0–8.4%), followed by females in region of Africa (3.8, 95% CI, 0.7–6.9%), while South-East Asia had a lowest CT prevalence 0.8% (95% CI, 0.3–1.3%). Conclusions This study provided the updated prevalence of CT among general population worldwide. General population from Latin America, especially females, and women in Africa should be given priority by WHO when design and delivery CT control programs.http://link.springer.com/article/10.1186/s12879-020-05307-wChlamydia trachomatisPrevalenceGeneral populationMeta-analysis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pengcheng Huai Furong Li Tongsheng Chu Dianchang Liu Jian Liu Furen Zhang |
spellingShingle |
Pengcheng Huai Furong Li Tongsheng Chu Dianchang Liu Jian Liu Furen Zhang Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis BMC Infectious Diseases Chlamydia trachomatis Prevalence General population Meta-analysis |
author_facet |
Pengcheng Huai Furong Li Tongsheng Chu Dianchang Liu Jian Liu Furen Zhang |
author_sort |
Pengcheng Huai |
title |
Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis |
title_short |
Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis |
title_full |
Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis |
title_fullStr |
Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis |
title_full_unstemmed |
Prevalence of genital Chlamydia trachomatis infection in the general population: a meta-analysis |
title_sort |
prevalence of genital chlamydia trachomatis infection in the general population: a meta-analysis |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2020-08-01 |
description |
Abstract Background Estimating prevalence of Chlamydia trachomatis (CT) worldwide is necessary in designing control programs and allocating health resources. We performed a meta-analysis to calculate the prevalence of CT in the general population. Methods The Pubmed and Embase databases were searched for eligible population-based studies from its inception through June 5, 2019. Q test and I 2 statistic were used to calculate the heterogeneity between studies. Random effects models were used to pool the prevalence of CT. Meta regression was performed to explore the possible sources of heterogeneity. Publication bias was evaluated using a funnel plot and “trim and fill” method. Results Twenty nine studies that reported prevalence of CT infection from 24 countries were identified, including a total population of 89,886 persons. The pooled prevalence of CT among the general population was 2.9% (95% CI, 2.4–3.5%), and females had a higher CT prevalence (3.1, 95% CI, 2.5–3.8%) than males (2.6, 95% CI, 2.0–3.2%) (χ 2 = 10.38, P < 0.01). Prevalence of CT was highest in region of America (4.5, 95% CI, 3.1–5.9%), especially in Latin America (6.7, 95% CI, 5.0–8.4%), followed by females in region of Africa (3.8, 95% CI, 0.7–6.9%), while South-East Asia had a lowest CT prevalence 0.8% (95% CI, 0.3–1.3%). Conclusions This study provided the updated prevalence of CT among general population worldwide. General population from Latin America, especially females, and women in Africa should be given priority by WHO when design and delivery CT control programs. |
topic |
Chlamydia trachomatis Prevalence General population Meta-analysis |
url |
http://link.springer.com/article/10.1186/s12879-020-05307-w |
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