Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia

Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia

Panaxynol (PAL) mainly comes from Umbelliferae plants, which has anti-inflammatory and neuroprotective activities. Lipopolysaccharide (LPS)-induced depression in mice was a classic model for studying the effects of drugs on depression in mice. The purpose of this study was to investigate the mechani...

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Bibliographic Details
Main Authors:	Yan Zhao, Xialin Sun, Tingwen Zhang, Shuangli Liu, Enbo Cai, Hongyan Zhu
Format:	Article
Language:	English
Published:	Elsevier 2021-06-01
Series:	Biomedicine & Pharmacotherapy
Subjects:	Panaxynol LPS-induced depression Oxidative stress NF-κB/IκB-α pathway BV-2 microglia
Online Access:	http://www.sciencedirect.com/science/article/pii/S0753332221001724

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