-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide
Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has bee...
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doaj-e6ebcdc259ce43b0bd0fb2cce3e7d2102020-11-24T23:47:14ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences 2008-38662008-38742016-02-011922012086546-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxideSiavash Parvardeh0Mahsa Moghimi1Pegah Eslami2Alireza Masoudi3Department of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Pharmacology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranObjective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate dependence and tolerance to morphine. Since a-terpineol is one of the bioactive phytochemical constituent of these medicinal plants, the present study was conducted to investigate the effects of a-terpineol on morphine-induced dependence and tolerance in mice. Materials and Methods: The mice were rendered dependent or tolerant to morphine by a 3-day administration schedule. The hot-plate test and naloxone-induced withdrawal syndrome were used to evaluate tolerance and dependence on morphine, respectively. To investigate a possible role for nitric oxide (NO) in the protective effect of a-terpineol, the NO synthase inhibitor, L-N(G)-nitroarginine methyl ester (L-NAME) and NO precursor, L-arginine, were used. Results: Administration of a-terpineol (5, 10, and 20 mg/kg, IP) significantly decreased the number of jumps in morphine dependent animals. Moreover, a-terpineol (20 and 40 mg/kg, IP) attenuated tolerance to the analgesic effect of morphine. The inhibitory effects of a-terpineol on morphine-induced dependence and tolerance were enhanced by pretreatment with L-NAME (10 mg/kg, IP). However, L-arginine (300 mg/kg, IP) antagonized the protective effects of a-terpineol on dependence and tolerance to morphine. Conclusion: These findings indicate that a-terpineol prevents the development of dependence and tolerance to morphine probably through the influence on NO production.http://ijbms.mums.ac.ir/article_6546_64083fa7fd5e543f236a120c7aa694d0.pdf-TerpineolDependenceMonoterpenoidMorphineNitric oxideTolerance |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Siavash Parvardeh Mahsa Moghimi Pegah Eslami Alireza Masoudi |
spellingShingle |
Siavash Parvardeh Mahsa Moghimi Pegah Eslami Alireza Masoudi -Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide Iranian Journal of Basic Medical Sciences -Terpineol Dependence Monoterpenoid Morphine Nitric oxide Tolerance |
author_facet |
Siavash Parvardeh Mahsa Moghimi Pegah Eslami Alireza Masoudi |
author_sort |
Siavash Parvardeh |
title |
-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide |
title_short |
-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide |
title_full |
-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide |
title_fullStr |
-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide |
title_full_unstemmed |
-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide |
title_sort |
-terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide |
publisher |
Mashhad University of Medical Sciences |
series |
Iranian Journal of Basic Medical Sciences |
issn |
2008-3866 2008-3874 |
publishDate |
2016-02-01 |
description |
Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate dependence and tolerance to morphine. Since a-terpineol is one of the bioactive phytochemical constituent of these medicinal plants, the present study was conducted to investigate the effects of a-terpineol on morphine-induced dependence and tolerance in mice.
Materials and Methods: The mice were rendered dependent or tolerant to morphine by a 3-day administration schedule. The hot-plate test and naloxone-induced withdrawal syndrome were used to evaluate tolerance and dependence on morphine, respectively. To investigate a possible role for nitric oxide (NO) in the protective effect of a-terpineol, the NO synthase inhibitor, L-N(G)-nitroarginine methyl ester (L-NAME) and NO precursor, L-arginine, were used.
Results: Administration of a-terpineol (5, 10, and 20 mg/kg, IP) significantly decreased the number of jumps in morphine dependent animals. Moreover, a-terpineol (20 and 40 mg/kg, IP) attenuated tolerance to the analgesic effect of morphine. The inhibitory effects of a-terpineol on morphine-induced dependence and tolerance were enhanced by pretreatment with L-NAME (10 mg/kg, IP). However, L-arginine (300 mg/kg, IP) antagonized the protective effects of a-terpineol on dependence and tolerance to morphine.
Conclusion: These findings indicate that a-terpineol prevents the development of dependence and tolerance to morphine probably through the influence on NO production. |
topic |
-Terpineol Dependence Monoterpenoid Morphine Nitric oxide Tolerance |
url |
http://ijbms.mums.ac.ir/article_6546_64083fa7fd5e543f236a120c7aa694d0.pdf |
work_keys_str_mv |
AT siavashparvardeh terpineolattenuatesmorphineinducedphysicaldependenceandtoleranceinmiceroleofnitricoxide AT mahsamoghimi terpineolattenuatesmorphineinducedphysicaldependenceandtoleranceinmiceroleofnitricoxide AT pegaheslami terpineolattenuatesmorphineinducedphysicaldependenceandtoleranceinmiceroleofnitricoxide AT alirezamasoudi terpineolattenuatesmorphineinducedphysicaldependenceandtoleranceinmiceroleofnitricoxide |
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