<i>Salmonella</i>-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy

<i>Salmonella</i>-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Restructures the Immune Contexture to Improve Checkpoint Blockade Efficacy

Therapeutic options for non-small cell lung cancer (NSCLC) treatment have changed dramatically in recent years with the advent of novel immunotherapeutic approaches. Among these, immune checkpoint blockade (ICB) using monoclonal antibodies has shown tremendous promise in approximately 20% of patient...

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Bibliographic Details
Main Authors: Nancy D. Ebelt, Edith Zuniga, Monica Marzagalli, Vic Zamloot, Bruce R. Blazar, Ravi Salgia, Edwin R. Manuel
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Biomedicines
Subjects:
non-small cell lung cancer
immune checkpoint blockade
anti-PD-1
anti-CTLA4
<i>Salmonella typhimurium</i>
small-hairpin RNA
Online Access:https://www.mdpi.com/2227-9059/8/12/617

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