The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity
Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when comp...
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| Language: | English |
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Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05395-y |
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doaj-e6ef202d9e6344acbce6ee90ed3c483d2021-05-11T10:20:03ZengNature Publishing GroupNature Communications2041-17232018-08-019111310.1038/s41467-018-05395-yThe chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicityChristopher W. Helsen0Joanne A. Hammill1Vivian W. C. Lau2Kenneth A. Mwawasi3Arya Afsahi4Ksenia Bezverbnaya5Lisa Newhook6Danielle L. Hayes7Craig Aarts8Bojana Bojovic9Galina F. Denisova10Jacek M. Kwiecien11Ian Brain12Heather Derocher13Katy Milne14Brad H. Nelson15Jonathan L. Bramson16Department of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityDepartment of Pathology and Molecular Medicine, McMaster UniversityTrev & Joyce Deeley Research Centre, British Columbia Cancer AgencyTrev & Joyce Deeley Research Centre, British Columbia Cancer AgencyTrev & Joyce Deeley Research Centre, British Columbia Cancer AgencyDepartment of Pathology and Molecular Medicine, McMaster UniversityChimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when compared with current CARs.https://doi.org/10.1038/s41467-018-05395-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Christopher W. Helsen Joanne A. Hammill Vivian W. C. Lau Kenneth A. Mwawasi Arya Afsahi Ksenia Bezverbnaya Lisa Newhook Danielle L. Hayes Craig Aarts Bojana Bojovic Galina F. Denisova Jacek M. Kwiecien Ian Brain Heather Derocher Katy Milne Brad H. Nelson Jonathan L. Bramson |
| spellingShingle |
Christopher W. Helsen Joanne A. Hammill Vivian W. C. Lau Kenneth A. Mwawasi Arya Afsahi Ksenia Bezverbnaya Lisa Newhook Danielle L. Hayes Craig Aarts Bojana Bojovic Galina F. Denisova Jacek M. Kwiecien Ian Brain Heather Derocher Katy Milne Brad H. Nelson Jonathan L. Bramson The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity Nature Communications |
| author_facet |
Christopher W. Helsen Joanne A. Hammill Vivian W. C. Lau Kenneth A. Mwawasi Arya Afsahi Ksenia Bezverbnaya Lisa Newhook Danielle L. Hayes Craig Aarts Bojana Bojovic Galina F. Denisova Jacek M. Kwiecien Ian Brain Heather Derocher Katy Milne Brad H. Nelson Jonathan L. Bramson |
| author_sort |
Christopher W. Helsen |
| title |
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity |
| title_short |
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity |
| title_full |
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity |
| title_fullStr |
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity |
| title_full_unstemmed |
The chimeric TAC receptor co-opts the T cell receptor yielding robust anti-tumor activity without toxicity |
| title_sort |
chimeric tac receptor co-opts the t cell receptor yielding robust anti-tumor activity without toxicity |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Chimeric antigen receptors (CARs) are effective tools for directing T cell killing of tumors, but may cause adverse side effects. Here the authors show that coupling of antigen-recognition and CD3-binding in a modular format induces more efficient anti-tumour responses but reduced toxicity when compared with current CARs. |
| url |
https://doi.org/10.1038/s41467-018-05395-y |
| work_keys_str_mv |
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1721448446936743936 |