SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL
Diabetes mellitus is associated with high morbidity and mortality among patients and its prevalence is increasing at an alarming rate worldwide. Insulin analogues are reported to have better efficacy and safety as compared to conventional insulin therapy, however, substantiation of data in different...
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doaj-e700cc1163194268aa9508dc372cda002020-11-24T22:14:51ZengUniversitas Gadjah MadaIndonesian Journal of Pharmacy2338-94272338-94862014-07-0125317418010.14499/indonesianjpharm25iss3pp174SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITALMohammad Ali Koladi0Chandar Batra1Mohammad Akhtar2 Shoaib Ahmad3 Shibli Jameel Ahmad4Shah Alam Khan5Al Khaleejy Polyclinics, Riyadh, Kingdom of Saudi Arabia.Dept of Endocrinology, Indraprastha Apollo Hospitals, New Delhi, India Dept of Pharma, Faculty of Pharmacy, Jamia Hamdard, New Delhi, IndiaRayat & Bahra Institute of Pharmacy, Sahauran, IndiaDept of Pharma, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India .Dept. of Pharmacy, Oman Medical College, Muscat, Sultanate of Oman. Diabetes mellitus is associated with high morbidity and mortality among patients and its prevalence is increasing at an alarming rate worldwide. Insulin analogues are reported to have better efficacy and safety as compared to conventional insulin therapy, however, substantiation of data in different geographical areas with genomic variation is yet to be established. The study was aimed to evaluate and compare the effectiveness and clinical safety profile of insulin analogues with regular insulin. In this prospective, randomized, observational study conducted at a Superspeciality hospital in India,78 diabetic patients on insulin therapy were recruited. The efficacy and safety markers of 24 patients on biphasic insulin analogue, 33 on recombinant insulin analogue and 21 on regular insulin were observed for 13 weeks. The collected data was statistically analyzed by using Instat software.The efficacy markers such as glycosylated hemoglobin, fasting and postprandial glucose values showed superior improvement with the insulin analogues at the end of 13 weeks study. Insulin analogues produced significantly fewer incidents of minor hypoglycemia without any significant alteration in BMI and weight gain. The results of our studies suggest that insulin analogues are safer and effective with regards to glycemic control and in the event of hypoglycemia over regular insulin.http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/218Body mass indexDiabetes mellitusInsulin analogueIndian populationglycosylated hemoglobin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mohammad Ali Koladi Chandar Batra Mohammad Akhtar Shoaib Ahmad Shibli Jameel Ahmad Shah Alam Khan |
spellingShingle |
Mohammad Ali Koladi Chandar Batra Mohammad Akhtar Shoaib Ahmad Shibli Jameel Ahmad Shah Alam Khan SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL Indonesian Journal of Pharmacy Body mass index Diabetes mellitus Insulin analogue Indian population glycosylated hemoglobin |
author_facet |
Mohammad Ali Koladi Chandar Batra Mohammad Akhtar Shoaib Ahmad Shibli Jameel Ahmad Shah Alam Khan |
author_sort |
Mohammad Ali Koladi |
title |
SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL |
title_short |
SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL |
title_full |
SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL |
title_fullStr |
SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL |
title_full_unstemmed |
SUBSTANTIATION ON SHORT TERM EFFICACY AND SAFETY OF INSULIN ANALOGUES IN NORTH INDIAN SUPERSPECIALITY HOSPITAL |
title_sort |
substantiation on short term efficacy and safety of insulin analogues in north indian superspeciality hospital |
publisher |
Universitas Gadjah Mada |
series |
Indonesian Journal of Pharmacy |
issn |
2338-9427 2338-9486 |
publishDate |
2014-07-01 |
description |
Diabetes mellitus is associated with high morbidity and mortality among patients and its prevalence is increasing at an alarming rate worldwide. Insulin analogues are reported to have better efficacy and safety as compared to conventional insulin therapy, however, substantiation of data in different geographical areas with genomic variation is yet to be established. The study was aimed to evaluate and compare the effectiveness and clinical safety profile of insulin analogues with regular insulin. In this prospective, randomized, observational study conducted at a Superspeciality hospital in India,78 diabetic patients on insulin therapy were recruited. The efficacy and safety markers of 24 patients on biphasic insulin analogue, 33 on recombinant insulin analogue and 21 on regular insulin were observed for 13 weeks. The collected data was statistically analyzed by using Instat software.The efficacy markers such as glycosylated hemoglobin, fasting and postprandial glucose values showed superior improvement with the insulin analogues at the end of 13 weeks study. Insulin analogues produced significantly fewer incidents of minor hypoglycemia without any significant alteration in BMI and weight gain. The results of our studies suggest that insulin analogues are safer and effective with regards to glycemic control and in the event of hypoglycemia over regular insulin. |
topic |
Body mass index Diabetes mellitus Insulin analogue Indian population glycosylated hemoglobin |
url |
http://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/218 |
work_keys_str_mv |
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