SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts

SPOP Mutations in Prostate Cancer across Demographically Diverse Patient Cohorts

BACKGROUND: Recurrent mutations in the Speckle-Type POZ Protein (SPOP) gene occur in up to 15% of prostate cancers. However, the frequency and features of cancers with these mutations across different populations is unknown. OBJECTIVE: To investigate SPOP mutations across diverse cohorts and valida...

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Main Authors: Mirjam Blattner, Daniel J. Lee, Catherine O'Reilly, Kyung Park, Theresa Y. MacDonald, Francesca Khani, Kevin R. Turner, Ya-Lin Chiu, Peter J. Wild, Igor Dolgalev, Adriana Heguy, Andrea Sboner, Sinan Ramazangolu, Haley Hieronymus, Charles Sawyers, Ashutosh K. Tewari, Holger Moch, Ghil Suk Yoon, Yong Chul Known, Ove Andrén, Katja Fall, Francecsa Demichelis, Juan Miguel Mosquera, Brian D. Robinson, Christopher E. Barbieri, Mark A. Rubin
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558614800031

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