The nature and epidemiology of OqxAB, a multidrug efflux pump
Abstract Background OqxAB efflux pump has been found to mediate multidrug resistance (MDR) in various bacteria over the past decades. The updates on the nature and epidemiology of OqxAB efflux pump need to be fully reviewed to broaden our understanding of this MDR determinant. Methods A literature s...
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doaj-e71471bcc9e24f7082820e483216084a2020-11-24T21:47:13ZengBMCAntimicrobial Resistance and Infection Control2047-29942019-02-018111310.1186/s13756-019-0489-3The nature and epidemiology of OqxAB, a multidrug efflux pumpJun Li0Heying Zhang1Jianan Ning2Abdul Sajid3Guyue Cheng4Zonghui Yuan5Haihong Hao6National Reference Laboratory of Veterinary Drug Residues (HZAU) and Key Laboratory of the Detection for Veterinary Drug ResiduesNational Reference Laboratory of Veterinary Drug Residues (HZAU) and Key Laboratory of the Detection for Veterinary Drug ResiduesNational Reference Laboratory of Veterinary Drug Residues (HZAU) and Key Laboratory of the Detection for Veterinary Drug ResiduesNational Reference Laboratory of Veterinary Drug Residues (HZAU) and Key Laboratory of the Detection for Veterinary Drug ResiduesLaboratory of Quality & Safety Risk Assessment for Livestock and Poultry Products (Wuhan), Ministry of Agriculture, P.R ChinaNational Reference Laboratory of Veterinary Drug Residues (HZAU) and Key Laboratory of the Detection for Veterinary Drug ResiduesNational Reference Laboratory of Veterinary Drug Residues (HZAU) and Key Laboratory of the Detection for Veterinary Drug ResiduesAbstract Background OqxAB efflux pump has been found to mediate multidrug resistance (MDR) in various bacteria over the past decades. The updates on the nature and epidemiology of OqxAB efflux pump need to be fully reviewed to broaden our understanding of this MDR determinant. Methods A literature search using the keyword of “oqxAB” was conducted in the online databases of Pubmed and ISI Web of Science with no restriction on the date of publication. The 87 publications were included into this review as references due to their close relevance to the nature and/or epidemiology of OqxAB efflux pump. Results The oqxAB gene generally locates on chromosome and/or plasmids flanked by IS26-like elements in clinical isolates of Enterobacteriaceae and Klebsiella pneumoniae, conferring low to intermediated resistance to quinoxalines, quinolones tigecycline, nitrofurantoin, several detergents and disinfectants (benzalkonium chloride, triclosan and SDS). It could co-spread with other antimicrobial resistance genes (bla CTX-M, rmtB and aac(6′)-Ib etc.), virulence genes and heavy metal resistance genes (pco and sil operons). Both RarA (activator) and OqxR (repressor) play important roles on regulation of the expression of OqxAB. Conclusions The dissemination of oqxAB gene may pose a great risk on food safety and public health. Further investigation and understanding of the natural functions, horizontal transfer, and regulation mechanism of the OqxAB efflux pump will aid in future strategies of antimicrobial usage.http://link.springer.com/article/10.1186/s13756-019-0489-3oqxABMultidrug efflux pumpQuinoxalinesQuinolonesTigecyclineNitrofurantoin |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jun Li Heying Zhang Jianan Ning Abdul Sajid Guyue Cheng Zonghui Yuan Haihong Hao |
spellingShingle |
Jun Li Heying Zhang Jianan Ning Abdul Sajid Guyue Cheng Zonghui Yuan Haihong Hao The nature and epidemiology of OqxAB, a multidrug efflux pump Antimicrobial Resistance and Infection Control oqxAB Multidrug efflux pump Quinoxalines Quinolones Tigecycline Nitrofurantoin |
author_facet |
Jun Li Heying Zhang Jianan Ning Abdul Sajid Guyue Cheng Zonghui Yuan Haihong Hao |
author_sort |
Jun Li |
title |
The nature and epidemiology of OqxAB, a multidrug efflux pump |
title_short |
The nature and epidemiology of OqxAB, a multidrug efflux pump |
title_full |
The nature and epidemiology of OqxAB, a multidrug efflux pump |
title_fullStr |
The nature and epidemiology of OqxAB, a multidrug efflux pump |
title_full_unstemmed |
The nature and epidemiology of OqxAB, a multidrug efflux pump |
title_sort |
nature and epidemiology of oqxab, a multidrug efflux pump |
publisher |
BMC |
series |
Antimicrobial Resistance and Infection Control |
issn |
2047-2994 |
publishDate |
2019-02-01 |
description |
Abstract Background OqxAB efflux pump has been found to mediate multidrug resistance (MDR) in various bacteria over the past decades. The updates on the nature and epidemiology of OqxAB efflux pump need to be fully reviewed to broaden our understanding of this MDR determinant. Methods A literature search using the keyword of “oqxAB” was conducted in the online databases of Pubmed and ISI Web of Science with no restriction on the date of publication. The 87 publications were included into this review as references due to their close relevance to the nature and/or epidemiology of OqxAB efflux pump. Results The oqxAB gene generally locates on chromosome and/or plasmids flanked by IS26-like elements in clinical isolates of Enterobacteriaceae and Klebsiella pneumoniae, conferring low to intermediated resistance to quinoxalines, quinolones tigecycline, nitrofurantoin, several detergents and disinfectants (benzalkonium chloride, triclosan and SDS). It could co-spread with other antimicrobial resistance genes (bla CTX-M, rmtB and aac(6′)-Ib etc.), virulence genes and heavy metal resistance genes (pco and sil operons). Both RarA (activator) and OqxR (repressor) play important roles on regulation of the expression of OqxAB. Conclusions The dissemination of oqxAB gene may pose a great risk on food safety and public health. Further investigation and understanding of the natural functions, horizontal transfer, and regulation mechanism of the OqxAB efflux pump will aid in future strategies of antimicrobial usage. |
topic |
oqxAB Multidrug efflux pump Quinoxalines Quinolones Tigecycline Nitrofurantoin |
url |
http://link.springer.com/article/10.1186/s13756-019-0489-3 |
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