Impaired cross-talk between the thioredoxin and glutathione systems is related to ASK-1 mediated apoptosis in neuronal cells exposed to mercury
Mercury (Hg) compounds target both cysteine (Cys) and selenocysteine (Sec) residues in peptides and proteins. Thus, the components of the two major cellular antioxidant systems – glutathione (GSH) and thioredoxin (Trx) systems – are likely targets for mercurials. Hg exposure results in GSH depletion...
Main Authors: | Vasco Branco, Lucia Coppo, Susana Solá, Jun Lu, Cecília M.P. Rodrigues, Arne Holmgren, Cristina Carvalho |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2017-10-01
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Series: | Redox Biology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2213231717303099 |
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