Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon. However, the nucleus incertus (NI) of the pontine tegmentum p...
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doaj-e71df40bcca24eb49a9e39d925c10dc32021-03-18T05:45:24ZengFrontiers Media S.A.Frontiers in Neuroanatomy1662-51292021-03-011510.3389/fnana.2021.637922637922Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit MemoryIsis Gil-Miravet0Aroa Mañas-Ojeda1Francisco Ros-Bernal2Esther Castillo-Gómez3Esther Castillo-Gómez4Hector Albert-Gascó5Andrew L. Gundlach6Francisco E. Olucha-Bordonau7Francisco E. Olucha-Bordonau8Unitat Predepartamental de Medicina, Facultat de Ciències de la Salut, Universitat Jaume I, Castelló de la Plana, SpainUnitat Predepartamental de Medicina, Facultat de Ciències de la Salut, Universitat Jaume I, Castelló de la Plana, SpainUnitat Predepartamental de Medicina, Facultat de Ciències de la Salut, Universitat Jaume I, Castelló de la Plana, SpainUnitat Predepartamental de Medicina, Facultat de Ciències de la Salut, Universitat Jaume I, Castelló de la Plana, SpainCentro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, SpainDepartment of Clinical Neurosciences, UK Dementia Research Institute, University of Cambridge, Cambridge, United KingdomThe Florey Institute for Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, AustraliaUnitat Predepartamental de Medicina, Facultat de Ciències de la Salut, Universitat Jaume I, Castelló de la Plana, SpainCentro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Madrid, SpainTelencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon. However, the nucleus incertus (NI) of the pontine tegmentum provides a strong GABAergic and peptidergic innervation of the hippocampus, basal forebrain, amygdala, prefrontal cortex, and related regions; and represents a parallel source of ascending modulation of cognitive and emotional domains. NI GABAergic neurons express multiple peptides, including neuromedin-B, cholecystokinin, and relaxin-3, and receptors for stress and arousal transmitters, including corticotrophin-releasing factor and orexins/hypocretins. A functional relationship exists between NI neurons and their associated peptides, relaxin-3 and neuromedin-B, and hippocampal theta rhythm, which in turn, has a key role in the acquisition and extinction of declarative and emotional memories. Furthermore, RXFP3, the cognate receptor for relaxin-3, is a Gi/o protein-coupled receptor, and its activation inhibits the cellular accumulation of cAMP and induces phosphorylation of ERK, processes associated with memory formation in the hippocampus and amygdala. Therefore, this review summarizes the role of NI transmitter systems in relaying stress- and arousal-related signals to the higher neural circuits and processes associated with memory formation and retrieval.https://www.frontiersin.org/articles/10.3389/fnana.2021.637922/fullneuropeptideRXFP3GABAbrainstemamygdalahippocampus |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Isis Gil-Miravet Aroa Mañas-Ojeda Francisco Ros-Bernal Esther Castillo-Gómez Esther Castillo-Gómez Hector Albert-Gascó Andrew L. Gundlach Francisco E. Olucha-Bordonau Francisco E. Olucha-Bordonau |
spellingShingle |
Isis Gil-Miravet Aroa Mañas-Ojeda Francisco Ros-Bernal Esther Castillo-Gómez Esther Castillo-Gómez Hector Albert-Gascó Andrew L. Gundlach Francisco E. Olucha-Bordonau Francisco E. Olucha-Bordonau Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory Frontiers in Neuroanatomy neuropeptide RXFP3 GABA brainstem amygdala hippocampus |
author_facet |
Isis Gil-Miravet Aroa Mañas-Ojeda Francisco Ros-Bernal Esther Castillo-Gómez Esther Castillo-Gómez Hector Albert-Gascó Andrew L. Gundlach Francisco E. Olucha-Bordonau Francisco E. Olucha-Bordonau |
author_sort |
Isis Gil-Miravet |
title |
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory |
title_short |
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory |
title_full |
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory |
title_fullStr |
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory |
title_full_unstemmed |
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory |
title_sort |
involvement of the nucleus incertus and relaxin-3/rxfp3 signaling system in explicit and implicit memory |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroanatomy |
issn |
1662-5129 |
publishDate |
2021-03-01 |
description |
Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to the telencephalon. However, the nucleus incertus (NI) of the pontine tegmentum provides a strong GABAergic and peptidergic innervation of the hippocampus, basal forebrain, amygdala, prefrontal cortex, and related regions; and represents a parallel source of ascending modulation of cognitive and emotional domains. NI GABAergic neurons express multiple peptides, including neuromedin-B, cholecystokinin, and relaxin-3, and receptors for stress and arousal transmitters, including corticotrophin-releasing factor and orexins/hypocretins. A functional relationship exists between NI neurons and their associated peptides, relaxin-3 and neuromedin-B, and hippocampal theta rhythm, which in turn, has a key role in the acquisition and extinction of declarative and emotional memories. Furthermore, RXFP3, the cognate receptor for relaxin-3, is a Gi/o protein-coupled receptor, and its activation inhibits the cellular accumulation of cAMP and induces phosphorylation of ERK, processes associated with memory formation in the hippocampus and amygdala. Therefore, this review summarizes the role of NI transmitter systems in relaying stress- and arousal-related signals to the higher neural circuits and processes associated with memory formation and retrieval. |
topic |
neuropeptide RXFP3 GABA brainstem amygdala hippocampus |
url |
https://www.frontiersin.org/articles/10.3389/fnana.2021.637922/full |
work_keys_str_mv |
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