Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study.
BACKGROUND: Non-syndromic clefts of the orofacial region occur in approximately 1 per 500 to 2,500 live births, depending on geographical area and ethnicity. It can be supposed that the disruption of the normal facial structure and the long-standing pressure of treatment from birth to adulthood brin...
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doaj-e71e2b3e37394a4fa314c0b98685a7fa2020-11-25T01:29:12ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-0177e4101510.1371/journal.pone.0041015Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study.Volker GasslingPaul-Martin HolterhusDorothee HerbersAlexandra KulleUwe NiederbergerJürgen HedderichJörg WiltfangWolf-Dieter GerberBACKGROUND: Non-syndromic clefts of the orofacial region occur in approximately 1 per 500 to 2,500 live births, depending on geographical area and ethnicity. It can be supposed that the disruption of the normal facial structure and the long-standing pressure of treatment from birth to adulthood bring about a range of life stressors which may lead to a long-lasting impact on affected subjects throughout their lives. Therefore, the present study aimed to assess different aspects of psychosocial stress in affected individuals. METHODS: The study was divided into two parts: first, the Trier Social Stress Test which involves uncontrollability and high levels of social-evaluative stress under real conditions and second, the query of various aspects of coping with psychosocial stress. The test group consisted of 30 affected adult subjects, and an equally sized control group of unaffected volunteers. Cortisol dysregulation was determined by saliva samples before and after stress induction. Meanwhile, participants were asked to complete the SVF 120 stress-coping questionnaire. RESULTS: The analysis of saliva samples showed a similar baseline concentration as well as a similar increase in cortisol levels after stress induction for both groups. Subsequently, the decline in cortisol concentrations was significantly faster in the CLP group (course: p<0.001; groups: p = 0.102; interaction: p = 0.167). The evaluation of the stress-coping questionnaire revealed a significantly shorter rumination about a stressful event in individuals with CLP-related malformations (p = 0.03). CONCLUSION: We conclude that adults with CLP have significantly better stress-coping strategies than their healthy peers. TRIAL REGISTRATION: German Clinical Trials Organization DRKS00003466.http://europepmc.org/articles/PMC3401206?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Volker Gassling Paul-Martin Holterhus Dorothee Herbers Alexandra Kulle Uwe Niederberger Jürgen Hedderich Jörg Wiltfang Wolf-Dieter Gerber |
spellingShingle |
Volker Gassling Paul-Martin Holterhus Dorothee Herbers Alexandra Kulle Uwe Niederberger Jürgen Hedderich Jörg Wiltfang Wolf-Dieter Gerber Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study. PLoS ONE |
author_facet |
Volker Gassling Paul-Martin Holterhus Dorothee Herbers Alexandra Kulle Uwe Niederberger Jürgen Hedderich Jörg Wiltfang Wolf-Dieter Gerber |
author_sort |
Volker Gassling |
title |
Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study. |
title_short |
Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study. |
title_full |
Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study. |
title_fullStr |
Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study. |
title_full_unstemmed |
Stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study. |
title_sort |
stress-coping and cortisol analysis in patients with non-syndromic cleft lip and palate: an explorative study. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2012-01-01 |
description |
BACKGROUND: Non-syndromic clefts of the orofacial region occur in approximately 1 per 500 to 2,500 live births, depending on geographical area and ethnicity. It can be supposed that the disruption of the normal facial structure and the long-standing pressure of treatment from birth to adulthood bring about a range of life stressors which may lead to a long-lasting impact on affected subjects throughout their lives. Therefore, the present study aimed to assess different aspects of psychosocial stress in affected individuals. METHODS: The study was divided into two parts: first, the Trier Social Stress Test which involves uncontrollability and high levels of social-evaluative stress under real conditions and second, the query of various aspects of coping with psychosocial stress. The test group consisted of 30 affected adult subjects, and an equally sized control group of unaffected volunteers. Cortisol dysregulation was determined by saliva samples before and after stress induction. Meanwhile, participants were asked to complete the SVF 120 stress-coping questionnaire. RESULTS: The analysis of saliva samples showed a similar baseline concentration as well as a similar increase in cortisol levels after stress induction for both groups. Subsequently, the decline in cortisol concentrations was significantly faster in the CLP group (course: p<0.001; groups: p = 0.102; interaction: p = 0.167). The evaluation of the stress-coping questionnaire revealed a significantly shorter rumination about a stressful event in individuals with CLP-related malformations (p = 0.03). CONCLUSION: We conclude that adults with CLP have significantly better stress-coping strategies than their healthy peers. TRIAL REGISTRATION: German Clinical Trials Organization DRKS00003466. |
url |
http://europepmc.org/articles/PMC3401206?pdf=render |
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