Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients
Objective The aim of this cross-sectional questionnaire-based study was to identify associations between the doses of cannabinoids and terpenes administered, and symptoms of attention deficit hyperactivity disorder (ADHD). Methods Participants were adult patients licensed for medical cannabis (MC...
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doaj-e7279373bdff4449bf6ca6ae83aa87f42020-11-25T00:29:30ZengRambam Health Care CampusRambam Maimonides Medical Journal2076-91722020-01-01111e000110.5041/RMMJ.10384Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis PatientsJeffrey Y. Hergenrather0Joshua Aviram1Yelena Vysotski2Salvatore Campisi-Pinto3Gil M. Lewitus4David Meiri5Faculty of Biology, Technion–Israel Institute of Technology, Haifa, IsraelFaculty of Biology, Technion–Israel Institute of Technology, Haifa, IsraelFaculty of Biology, Technion–Israel Institute of Technology, Haifa, IsraelFaculty of Biology, Technion–Israel Institute of Technology, Haifa, IsraelFaculty of Biology, Technion–Israel Institute of Technology, Haifa, IsraelFaculty of Biology, Technion–Israel Institute of Technology, Haifa, IsraelObjective The aim of this cross-sectional questionnaire-based study was to identify associations between the doses of cannabinoids and terpenes administered, and symptoms of attention deficit hyperactivity disorder (ADHD). Methods Participants were adult patients licensed for medical cannabis (MC) treatment who also reported a diagnosis of ADHD by a physician. Data on demographics, ADHD, sleep, and anxiety were collected using self-report questionnaires. Data collected on MC treatment included administration route, cultivator, cultivar name, and monthly dose. Comparison statistics were used to evaluate differences in reported parameters between low (20–30 g, n=18) and high (40–70 g, n=35) MC monthly dose and low adult ADHD self-report scale (ASRS, 0–5) score (i.e. ≤3.17 score, n=30) or high ASRS score (i.e. ≥3.18 score, n=29) subgroups. Results From the 59 patients that answered the questionnaire, MC chemovar could be calculated for 27 (45%) of them. The high MC monthly dose group consumed higher levels of most phyto-cannabinoids and terpenes, but that was not the case for all of the cannabis components. The high dose consumers and the ones with lower ASRS score reported a higher occurrence of stopping all ADHD medications. Moreover, there was an association between lower ASRS score subgroup and lower anxiety scores. In addition, we found an association between lower ASRS score and consumption of high doses of cannabinol (CBN), but not with Δ-9-tetrahydrocannabinol (THC). Conclusion These findings reveal that the higher-dose consumption of MC components (phyto-cannabinoids and terpenes) is associated with ADHD medication reduction. In addition, high dosage of CBN was associated with a lower ASRS score. However, more studies are needed in order to fully understand if cannabis and its constituents can be used for management of ADHD.https://www.rmmj.org.il/issues/44/1038/manuscriptadhdcannabiscannabinoids |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jeffrey Y. Hergenrather Joshua Aviram Yelena Vysotski Salvatore Campisi-Pinto Gil M. Lewitus David Meiri |
spellingShingle |
Jeffrey Y. Hergenrather Joshua Aviram Yelena Vysotski Salvatore Campisi-Pinto Gil M. Lewitus David Meiri Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients Rambam Maimonides Medical Journal adhd cannabis cannabinoids |
author_facet |
Jeffrey Y. Hergenrather Joshua Aviram Yelena Vysotski Salvatore Campisi-Pinto Gil M. Lewitus David Meiri |
author_sort |
Jeffrey Y. Hergenrather |
title |
Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients |
title_short |
Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients |
title_full |
Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients |
title_fullStr |
Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients |
title_full_unstemmed |
Cannabinoid and Terpenoid Doses are Associated with Adult ADHD Status of Medical Cannabis Patients |
title_sort |
cannabinoid and terpenoid doses are associated with adult adhd status of medical cannabis patients |
publisher |
Rambam Health Care Campus |
series |
Rambam Maimonides Medical Journal |
issn |
2076-9172 |
publishDate |
2020-01-01 |
description |
Objective
The aim of this cross-sectional questionnaire-based study was to identify associations between the doses of cannabinoids and terpenes administered, and symptoms of attention deficit hyperactivity disorder (ADHD).
Methods
Participants were adult patients licensed for medical cannabis (MC) treatment who also reported a diagnosis of ADHD by a physician. Data on demographics, ADHD, sleep, and anxiety were collected using self-report questionnaires. Data collected on MC treatment included administration route, cultivator, cultivar name, and monthly dose. Comparison statistics were used to evaluate differences in reported parameters between low (20–30 g, n=18) and high (40–70 g, n=35) MC monthly dose and low adult ADHD self-report scale (ASRS, 0–5) score (i.e. ≤3.17 score, n=30) or high ASRS score (i.e. ≥3.18 score, n=29) subgroups.
Results
From the 59 patients that answered the questionnaire, MC chemovar could be calculated for 27 (45%) of them. The high MC monthly dose group consumed higher levels of most phyto-cannabinoids and terpenes, but that was not the case for all of the cannabis components. The high dose consumers and the ones with lower ASRS score reported a higher occurrence of stopping all ADHD medications. Moreover, there was an association between lower ASRS score subgroup and lower anxiety scores. In addition, we found an association between lower ASRS score and consumption of high doses of cannabinol (CBN), but not with Δ-9-tetrahydrocannabinol (THC).
Conclusion
These findings reveal that the higher-dose consumption of MC components (phyto-cannabinoids and terpenes) is associated with ADHD medication reduction. In addition, high dosage of CBN was associated with a lower ASRS score. However, more studies are needed in order to fully understand if cannabis and its constituents can be used for management of ADHD. |
topic |
adhd cannabis cannabinoids |
url |
https://www.rmmj.org.il/issues/44/1038/manuscript |
work_keys_str_mv |
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